2020年1月23日 · p62/SQSTM1 is an autophagy receptor and signaling adaptor with an N-terminal PB1 domain that forms the scaffold of phase-separated p62 bodies in the cell. The molecular determinants that...

p62（也称为SQSTM1蛋白），由以下三个结构域组成：N端Phox和Bem1 (PB1)结构域、锌指结构域和C端泛素相关(UBA)结构域。 研究表明，p62蛋白锌指结构域和UBA结构域之间的连接区域（LRS区域）负责与自噬受体蛋白 Atg8/LC3结合，UBA结构域负责招募泛素化蛋白。

2018年3月5日 · The PB1 domain and UBA domain of p62 are required for polyubiquitin chain-induced phase separation and autophagic degradation of p62. p62 has an N-terminal PB1 domain and a C-terminal...

2021年9月1日 · Here we employ in vitro reconstitution and cell biology to define the roles of the human cargo receptors p62/SQSTM1, NBR1 and TAX1BP1 in the selective autophagy of ubiquitinated substrates. We...

We identified a mechanism of regulation of p62/SQSTM1 where the ZZ and the PB1 domains regulate the exposure of the LIR-sequence to enable or inhibit the interaction with LC3B. A mutation to mimic the phosphorylation of a site on the ZZ domain leads to …

2018年9月18日 · We determined the importance of the protein p62 in the formation of ALIS and demonstrated that two domains of p62—PB1 and UBA—are essential for ALIS assembly. Those two major binding domains of p62, also known as sequestosome 1, were shown to play a critical role in the formation of autophagosomes or cytoplasmic aggregates.

2018年9月18日 · Those two major binding domains of p62, also known as sequestosome 1, were shown to play a critical role in the formation of autophagosomes or cytoplasmic aggregates. Specifically, the PB1 domain is essential for self-oligomerization, and the UBA domain allows p62 to bind to polyubiquitin chains or ubiquitinated proteins.

p62, also known as SQSTM1, is a multi-domain signalling scaffold protein involved in numerous critical cellular functions such as autophagy, apoptosis and inflammation. Crucial interactions relevant to these functions are mediated by the N-terminal Phox and Bem1p (PB1) domain, which is divided into …

2009年8月29日 · The p62 plays important roles in the ubiquitin-proteasome system, autophagy, and NF-κB signaling pathway, through the PB1–PB1 interaction with its own PB1, Par6 PB1, aPKC PB1, MEK5 PB1, Nbr1 PB1, as well as the non canonical PB1–PB1 interaction with the S5a and Rpt1 subunits of the proteasomes, ERK and LCK.

2015年5月5日 · This cryo-EM study reveals that p62 forms a helical assembly built from a core PB1 strand scaffold with the C-terminal part of p62 attached to host binding sites with interacting partners of p62 that have been described (Bjørkøy et al., 2005, Pankiv et al., 2007, Jain et al., 2010), in particular, LC3, KEAP1, and ubiquitin.