2025年3月30日 · SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA …

Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene. [5] [6] [7] Also known as the ubiquitin-binding protein p62, [8] it is an autophagosome cargo protein that …

2020年3月3日 · p62调控nf-κb主要有两种方式，其一是通过pb1结构域结合apkc、zz结构域结合rip，激活tnf-α信号介导的 nf-κb 通路；其二是通过 tb 结构域结合traf，形成p62-traf6-ikkβapkc …

p62 is a highly conserved, multi-domain, and multi-functional adaptor protein critically involved in several important cellular processes. Via its pronounced domain architecture, p62 binds to …

new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and …

2010年7月16日 · Our data explain how p62 contributes to activation of NRF2 target genes in response to oxidative stress through creating a positive feedback loop. The p62/SQSTM1 …

2025年3月26日 · This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a …

2021年1月4日 · In this report, we describe the properties of endogenous p62-bodies, the effect of autophagosome biogenesis on these bodies, and the in vivo significance of their turnover. p62 …

In this review, we highlight recent advances in understanding the role of p62 in coordinating the ubiquitin-proteasome system and autophagy. We also discuss positive and negative effects of …

1998年9月18日 · p62 is a novel immediate early response gene encoding a ubiquitin chain binding protein. To investigate the mechanism of p62 gene expression, we isolated and …