2022年2月9日 · Using p53 -null orthotopic and ectopic models of murine HCC, we find that combining CXCR4-targeted p53 mRNA nanoparticles with anti-PD-1 therapy effectively induces global reprogramming of...

p53 mRNA的选择性翻译产生两种同源异构体：p53全长（p53FL）和p53/p47。 p53全长（p53FL） :在DNA损伤后激活 ATM激酶 （ 毛细血管扩张性共济失调症突变蛋白 ）从 +1 AUG 诱导p53FL合成。

The p53 mRNA also plays a role in regulating p53 activity and this review focuses on different ways by which the p53 mRNA helps differentiate p53-mediated response to signalling pathways. We describe how the p53 mRNA affects post-translational modifications and the stability of the nascent protein as well as the expression of p53 isoforms with ...

通过阻断p53与MDM2之间的相互作用，研究者们希望，携带野生型p53的患者能够恢复p53的抑癌活性。 p53和MDM2（来源：Nature Reviews Drug Discovery） 然而，靶向蛋白质-蛋白质相互作用(PPIs)也有自己的挑战。

Here, a redox-responsive nanoparticle (NP) platform is engineered for effective delivery of p53 -encoding synthetic messenger RNA (mRNA). We demonstrate that the synthetic p53 -mRNA NPs markedly delay the growth of p53 -null HCC and NSCLC cells …

2019年4月23日 · We also describe how a p53 mRNA platform shows riboswitch-like features and controls the rate of p53 synthesis, protein stability and modifications of the nascent p53 protein. A single cancer-derived synonymous mutation disrupts the folding of this platform and prevents p53 activation following DNA damage.

2025年3月2日 · 在最近的一项研究中，在HCC和NSCLC小鼠模型中，通过纳米颗粒递送p53 mRNA使p53缺失的肺癌细胞存活率显著降低，肿瘤大小显著减小。 此外，与单独的治疗相比，p53 mRNA纳米颗粒与免疫治疗相结合可提高抗癌效果。

In a highly focused study, Fahreus and colleagues (Karakostis et al., 2019) describe how the interaction of p53 mRNA with the Mdm2 protein opens up new processes by which p53 translation is controlled. Emphasizing the role of the RNA itself, they show profound effects of synonymous mutations in the coding region of p53.

The tumor suppressor p53 can trigger tumor resistance to chemotherapy by facilitating DNA damage repair and maintaining genomic integrity. ... as determined by the RIP assay. (G) Knockdown of p53 elevates the levels of SFPQ mRNA. (H) Schematic illustration of the potential p53-REs within the promoter and the first exon of SFPQ. (I) p53 binds to ...

In addition, YTH structural domain family 2 (YTHDF2) was found to promote M2 polarization by destabilizing p53 mRNA [62,65]. In addition to regulating macrophage polarization, p53 can interact with macrophages in other ways. For example, p53 in macrophages leads to anti-inflammatory responses by inhibiting STAT1 .