2022年3月15日 · Here, we provide a comprehensive overview of molecular interactions between the p53 and Wnt pathway discovered in cancer, including complex feedback loops and reciprocal transactivation. The mutational landscape of genes associated with p53 and Wnt signaling is described, including mutual exclusive and co-occurring genetic alterations.

The main inhibitory effects of p53 on Wnt signaling include GSK3β and SIAH1-dependent ubiquitination of β-catenin, miRNA and lncRNA-mediated repression of Wnt target genes, and induction of secreted Wnt antagonists such as DKK1 (B). p53 stimulates Wnt signaling by increasing the expression of different WNT ligands and Fzd receptors (C).

2021年5月21日 · Our study advanced understanding in two fundamental subjects: (1) identification of p53 as a key node negatively involved in Wnt/ß-catenin-mediated osteogenesis; (2) revealing of a stepwise ...

2019年7月31日 · Loss of p53 in mouse models of breast cancer leads to activation of WNT signalling, which promotes metastatic spread by inducing systemic neutrophilic inflammation.

2017年1月5日 · In this study, we outline a regulatory network that involves the p53 tumor suppressor family and the Wnt pathway acting together with the TGF-β pathway in mesendodermal differentiation of mouse and human embryonic stem cells. Knockout of all three members, p53, p63, and p73, shows that the p53 famil …

2020年10月21日 · In this study, we demonstrate that 5-FU activates CSCs via p53-induced WNT3 transcription, which is followed by activation of the WNT/β-catenin pathway in CRC cell lines and xenograft tumors as...

Approximately half of all cancers have p53 inactivating mutations, in addition to which most malignancies inactivate the p53 pathway by increasing p53 inhibitors, decreasing p53 activators, or inactivating p53 downstream targets. ... p53 gene deletion increases neutrophil levels through uncontrolled WNT signaling, leading to metastasis . (7 ...

6 天之前 · The Wnt signaling pathway plays a crucial role in development and tissue homeostasis, regulating key cellular processes such as proliferation, differentiation, and apoptosis. However, its abnormal activation is strongly associated with tumorigenesis, metastasis, and resistance to therapy, making it a vital target for cancer treatment. This review provides a comprehensive insight into the role ...

Loss of p53 function increases canonical Wnt signaling through miR-34-specific interactions with target UTRs, whereas miR-34 depletion relieves p53-mediated Wnt repression. Further, gene expression signatures reflecting the status of β-catenin-TCF/LEF transcriptional activity in breast cancer and pediatric neuroblastoma patients are closely ...

2015年12月1日 · We present the mechanism of interaction of Wnt network module, which is responsible for periodic somitogenesis, with p 53 regulatory network, which is one of the main regulators of various cellular functions, and switching of various oscillating states by investigating p 53–Wnt model.