PUMA is involved in p53-dependent and -independent apoptosis induced by a variety of signals, and is regulated by transcription factors, not by post-translational modifications. After activation, PUMA interacts with antiapoptotic Bcl-2 family members, thus freeing Bax and/or Bak which are then able to signal apoptosis to the mitochondria.

We have identified a novel gene named PUMA (p53 upregulated modulator of apoptosis) as a target for activation by p53. This gene encodes two BH3 domain-containing proteins (PUMA-alpha and PUMA-beta) that are induced in cells following p53 activation.

摘 要：PUMA(p53 up-regulated modulator of apoptosis)是Bcl-2蛋白家族的促凋亡成员之一，具有强 大的促凋亡作用。 研究发现PUMA表达水平的降低与肿瘤的发生密切相关，上调PUMA在肿瘤细胞中

2021年6月30日 · To evaluate the importance of key stress response components in vivo, we have generated zebrafish null alleles in puma, noxa, p53, p63, and p73. Utilizing these genetic mutants, we have...

2001年3月1日 · In this study, we have identified PUMA as a novel p53-inducible gene that encodes BH3 domain–containing proteins with strong proapoptotic activity. The rapid induction of PUMA mRNA and the presence of a p53 binding site in the first intron of PUMA indicate that PUMA is a direct transcriptional target of p53.

有趣的是，Bcl2 家族基因的一个关键亚群是 p53 的靶标，包括 BAX、Noxa、PUMA（p53 上调的凋亡调节因子）和最近发现的 BID（BH3 相互作用结构域死亡激动剂）。

PUMA(p53上调的凋亡因子)是一个Bcl-2家族的BH3-only蛋白,它最初是作为p53的直接靶向基因被鉴定出来。 而作为p53的重要下游因子,PUMA(p53上调的凋亡因子)在癌细胞凋亡的过程中发挥了重要的作用。

2009年7月30日 · PUMA (p53 upregulated modulator of apoptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2 family member and a critical mediator of p53-dependent and -independent apoptosis...

High expression levels of PUMA are correlated with decreased mitochondrial pyruvate uptake and increased glycolysis in HCCs and poor prognosis of HCC patients. These findings are instrumental for cancer drug discovery aiming at activating WTp53 or …

2005年9月9日 · An unexpected stressful “jolt” to the cell, such as DNA damage or oncogene activation, results in a rapid increase of nuclear p53 and transcriptional activation of PUMA expression. PUMA then binds to Bcl-xL, hence freeing p53 to activate Bax.