杨大俊点评 | 颠覆认知：p53“铁搭档”MDM2，竟是抗癌帮手 - 知乎
apg-115对携带功能性p53的肿瘤细胞是一种强有效的p53–mdm2相互作用小分子抑制剂。为了调查apg-115是否会影响t细胞中mdm2的表达和功能，研究人员用apg-115处理人类和小鼠的t细胞。 …
Cancer Cell：顾伟/刘彦卿等2万字长文综述全面总结p53领域研究 …
2024年5月10日 · mdm2和mdmx结合p53的tad以抑制其转录激活活性（不依赖于与mdm2作为e3泛素连接酶的作用）。 多种转录调节因子（例如PBRM1、SET和Dicer）能够与p53相互作用。 …
The MDM2-p53 pathway revisited - PMC - PubMed Central (PMC)
In normal cells, p53 is kept at low levels by murine double minute 2 (MDM2), an ubiquitin ligase. MDM2 and p53 form a negative-feedback loop, in which p53 induces the expression of MDM2, …
Mdm2-mediated ubiquitylation: p53 and beyond - Nature
2009年6月5日 · New biochemical and genetic data have recently provided important insights into Mdm2-mediated control of p53 and how the physical and functional interactions between …
MDM2小分子抑制剂的临床研究进展 - 知乎 - 知乎专栏
小鼠双微体2 (Murine double mimute 2, MDM2, 人源为HMD2) 是一种包含RING结构域的 E3泛素连接酶 ，MDM2能够与p53结合，阻断p53结合DNA发挥转录因子活性，促进p53单泛素化而排 …
Targeting MDM2-p53 interaction for breast cancer therapy - PMC
MDM2 overexpression may also be attributed to a mechanism that evades TP53-mediatedgrowth suppression. Dysregulation of the subcellular localization of MDM2 is another critical factor …
MDM2: current research status and prospects of tumor treatment
2024年5月13日 · Nutlin-3 stabilizes and activates p53, induces G1 and G2 phase cell cycle arrest and apoptosis in osteosarcoma (OS) cells, and is based on p53-MDM2, meaning that this …
MDM2: RING Finger Protein and Regulator of p53 - Madame …
The ability of MDM2 to promote the degradation and nuclear export of p53 depends on an intact RING finger domain located in the MDM2 C terminus. This chapter will discuss the …
MDM2 inhibition: an important step forward in cancer therapy
2020年7月10日 · Inhibiting the MDM2-p53 interaction with an MDM2 antagonist leads to reactivation of p53 in cancers with wild-type or functional p53. The interaction between MDM2 …
Frontiers | Identification of miR-342-5p/MDM4/p53 network in …
1 天前 · MDM4 forms heterodimers with MDM2 via its RING domains and enhances the degradation of p53 by stimulating MDM2 E3 ubiquitin ligase activity 51 . Loss of p53 function …