Mutant p53 suppresses innate immune signaling to promote …
We demonstrate that in cells lacking p53, cytoplasmic DNA triggers IRF3 transcriptional activity and apoptosis. In contrast, mtp53 blunts the TBK1-dependent activation of IRF3 thereby …
Interferon regulatory factor 3 activates p53-dependent cell growth ...
2006年10月28日 · Interferon regulatory factor 3 (IRF3) is a transcriptional factor that plays a crucial role in activation of innate immunity and inflammation in response to viral infection. We …
Mutant p53 suppresses innate immune signaling to promote ... - PubMed
2021年4月12日 · We report a mechanism by which mtp53 suppresses both cell-autonomous and non-cell-autonomous signaling to promote cancer cell survival and evasion of tumor immune …
Cancer Cell: p53突变影响天然免疫信号并促进肿瘤的免疫逃逸 - 癌 …
2021年4月13日 · 此外，诱导表达野生型p53的人肺癌H1299细胞中观察到TBK1，STING和IRF3磷酸化增加。 这些蛋白质的磷酸化可能反映了IFI16在p53介导下的活性，其与cGAS协同 ...
p53 engages the cGAS/STING cytosolic DNA sensing pathway for …
2023年1月19日 · We demonstrate that p53 requires the ubiquitin ligase TRIM24 to induce TREX1 degradation. The cytosolic DNA accumulation resulting from TREX1 degradation activates the …
Dual Role of p53 in Innate Antiviral Immunity - PMC
The recent findings by Shen and colleagues indicating that p53 levels are upregulated upon infection with influenza A virus, leading to IRF9 and Bax upregulation [46], are consistent with …
Mutant p53 - PubMed
2023年11月8日 · Further mechanistic studies revealed that p53 R213*/R211* instead of wild-type p53 interacted with TANK-binding kinase 1 (TBK1) and suppressed the innate immune TBK1 …
Interferon regulatory factor 3 activates p53-dependent cell growth ...
2006年10月28日 · When compared to control BJ cells, BJ cells which downregulated IRF3 by RNAi-mediated IRF3 knockdown showed extended in vitro life span. Taken together, the …
突变型p53促进肿瘤发生新机制—抑制天然免疫信号
2021年2月6日 · 进一步的实验发现，mtp53阻碍了STING/TBK1/IRF3通路激活后IRF3的核定位，并且mtp53可抑制HT-DNA诱导的依赖于IRF3的细胞凋亡，由此表明对于p53突变的细胞而言， …
《细胞》子刊：抑癌蛋白p53突变跳反！科学家首次发现，突变的p53 …
2021年2月8日 · 结果发现， 果然是突变的p53阻断了cGAS/STING/TBK1/IRF3这条先天性免疫信号通路。 只要抑制突变 TP53 基因的表达，跑最后一棒的IRF3就能被激活；只要突变的 TP53 …