p53功能获得突变与癌症进展和治疗 - 知乎 - 知乎专栏
突变p53通过转录抑制miR-130b上调EMT相关的关键转录因子ZEB1，促进EMT和癌细胞侵袭。 Mutp53还通过上调EMT相关转录因子Twist1并与p53家族成员p63相互作用，与Smad2形成复 …
p53 regulates epithelial-mesenchymal transition and stem cell ...
This study elucidates a role for p53 in regulating EMT-MET (mesenchymal-epithelial transition) and stemness or differentiation plasticity, and reveals a potential therapeutic implication to …
Interplay between p53 and non-coding RNAs in the regulation of EMT …
2021年1月4日 · Recent studies have highlighted a novel association of p53 and EMT where the mutation status of p53 is critically important for the outcome of this process. Interestingly, p53 …
PRMT1-p53 Pathway Controls Epicardial EMT and Invasion
2020年6月6日 · PRMT1 regulates splicing of Mdm4 and decreases p53 stability, which enhances Slug degradation to block epicardial EMT. The PRMT1-p53 axis is required for epicardial …
PRMT1-p53 Pathway Controls Epicardial EMT and Invasion
2020年6月9日 · Loss of PRMT1 leads to accumulation of p53 that enhances Slug degradation and blocks EMT. During heart development, the PRMT1-p53 pathway is required for epicardial …
Loss of p53 epigenetically modulates epithelial to mesenchymal ...
Loss of p53/Gain of function mutation in p53 activates the EMT programme, accompanied by an increased stem cell population via modulating the expression profile of various EMT-TFs …
Interplay between p53 and non-coding RNAs in the regulation of EMT …
Recent studies have highlighted a novel association of p53 and EMT where the mutation status of p53 is critically important for the outcome of this process. Interestingly, p53 has been shown to …
Mutant p53 gain-of-function induces epithelial–mesenchymal transition ...
2012年7月30日 · Here, we report that mutant p53 exerts oncogenic functions and promotes EMT in endometrial cancer (EC) by directly binding to the promoter of miR-130b (a negative …
p53-Mediated PI3K/AKT/mTOR Pathway Played a Role in PtoxDpt-Induced EMT ...
2019年5月5日 · Epithelial-mesenchymal transition (EMT) involves metastasis and drug resistance; thus, a new EMT reversing agent is required. It has shown that wild-type p53 can …
PRMT1 regulates splicing of Mdm4 and decreases p53 stability, which enhances Slug degradation to block epicardial EMT. The PRMT1-p53 axis is required for epicardial invasion …
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