P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene. [5][6] The product of this gene belongs to the family of purinoceptors for ATP. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay criteria. [7]

P2X7属于 嘌呤能受体家族 当中的一种，其家族共被分为两大类：分别是 G蛋白偶连P2Y受体 和 配体门控离子通道P2X受体。 P2X受体主要被细胞外的 ATP 激活开放，而P2X7由于对ATP的亲和性较低而与其他家族中的受体略有差异。 P2X7需要相较于生理浓度100-1000倍的胞外ATP浓度才能被激活，据报道其EC50值为大约100μM；但对BzATP的亲和度较高，其EC50大约为7μM。 P2X7受体 是一类非特异性阳离子通道，可以促进Na+和Ca2+的流入以及K+的外排，同时激 …

嘌呤能2X7受体 (purinergic 2X7 receptor, P2X7R)是一种离子通道型受体，可引起核苷酸结合寡聚化结构域样受体3 (nucleotide-binding oligomerization domain-like receptor protein 3, NLRP3)的激活，进而影响炎症细胞因子如IL-1β、IL-18等的释放从而参与多种炎症性疾病。

The P2X7R is an ATP gated ion channel, expressed by most immune cells, including the monocyte-derived cell lineages, T and B lymphocytes and their precursors. Here we give an overview of recent and established literature on the role of …

该基因的产物属于 ATP 嘌呤受体家族。 该受体作为配体门控离子通道发挥作用，并通过形成可渗透大分子的膜孔负责巨噬细胞的 ATP 依赖性裂解。 细胞质中 ATP 对这种核受体的激活可能是一种机制，通过这种机制，细胞活动可以与基因表达的变化相结合。 已经确定了多个可变剪接变体，其中大部分符合无义介导衰变 (NMD) 标准。 [RefSeq 提供，2010 年 7 月] The product of this gene belongs to the family of purinoceptors for ATP.

2024年2月29日 · The P2X7 receptor (P2X7R) is a kind of ligand (ATP)-gated ionotropic P2X receptors [1, 2, 3]. In light of the widespread presence of P2X7R expression across various immune cell types, including macrophages, neutrophils, and lymphocytes, this receptor plays a crucial role in immune responses [2, 4, 5].

The P2R most involved in inflammation and immunity is the P2X7 receptor (P2X7R), expressed by virtually all cells of innate and adaptive immunity. P2X7R mediates NLRP3 inflammasome activation, cytokine and chemokine release, T lymphocyte survival and differentiation, transcription factor activation, and cell death.

P2X7 receptor (P2X7R), a distinct ligand-gated ion channel, is a member of purinergic type 2 receptor family with ubiquitous expression in human body. Previous studies have revealed a pivotal role of P2X7R in innate and adaptive immunity. Once activated, it will meditate some vital cascaded response …

2024年1月16日 · When neurodegenerative diseases result in neuronal apoptosis and necrosis, ATP activates the P2X7R. This activation induces the release of biologically active molecules such as pro-inflammatory cytokines, chemokines, proteases, reactive oxygen species, and excitotoxic glutamate/ATP.

The anti-histamine clemastine was proposed as an extracellular binding positive allosteric modulator of the human recombinant P2X7R (transfected HEK-293) and natively expressed P2X7R (from human monocyte-derived macrophages and murine bone marrow macrophages) that sensitizes the receptor to lower ATP concentrations and facilitates its pore ...