P2RX7 - Wikipedia
P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene. [5] [6] The product of this gene belongs to the family of purinoceptors for ATP. Multiple alternatively spliced …
P2RX7 Gene - GeneCards | P2RX7 Protein | P2RX7 Antibody
2025年3月30日 · P2RX7 (Purinergic Receptor P2X 7) is a Protein Coding gene. Diseases associated with P2RX7 include Leukemia, Chronic Lymphocytic and Tularemia. Among its …
嘌呤能受体 P2X 7（P2RX7）基因 | MCE - MCE-生物活性分子大师
该基因的产物属于 ATP 嘌呤受体家族。 该受体作为配体门控离子通道发挥作用，并通过形成可渗透大分子的膜孔负责巨噬细胞的 ATP 依赖性裂解。 细胞质中 ATP 对这种核受体的激活可能 …
【每周一鼠】研究ATP能量运输的关键基因——P2rx7基因编辑小 …
P2rx7基因是ATP能量代谢通路中的关键基因。该基因编码上皮细胞和免疫效应细胞外的ATP门控阳离子通道，能够影响机体免疫系统的调控，影响炎症发生与癌症发展，是身体免疫调节的关 …
The purinergic receptor P2RX7 directs metabolic fitness of ... - Nature
2018年7月4日 · Here we show that P2RX7 is required for the establishment, maintenance and functionality of long-lived central and tissue-resident memory CD8 + T cell populations in mice. …
A small-molecule P2RX7 activator promotes anti-tumor immune ... - Nature
2021年1月28日 · We develop a chemical positive modulator (HEI3090) of the purinergic P2RX7 receptor that potentiates αPD-1 treatment to effectively control the growth of lung tumors in …
Genetics of the P2X7 receptor and human disease - PMC
The P2RX7 gene is highly polymorphic, and many single nucleotide polymorphisms (SNPs) underlie the wide variation observed in P2X7 receptor responses. We review the discovery of …
The P2X7 Receptor - PubMed
The P2X7 receptor is a trimeric ion channel gated by extracellular adenosine 5'-triphosphate. The receptor is present on an increasing number of different cells types including stem, blood, glial, …
P2RX7 purinergic receptor P2X 7 [ Homo sapiens (human) ]
2025年1月4日 · P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. Lucae S, et al. Hum Mol Genet, 2006 Aug 15. PMID …
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7
2025年2月11日 · P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy. The P2X7 Receptor Promotes Colorectal Inflammation and Tumorigenesis by Modulating Gut …