p53 和 p38 ：两种经典信号通路. 前言. p53是一种肿瘤抑制因子，在维持基因组稳定和限制细胞异常增殖方面具有重要功能。p38对一些转录因子具有磷酸化和激活的作用，包括p53。二者相关的信号通路在细胞周期调控过程中效应广泛，是肿瘤、炎症治疗的热门研究靶 ...

p38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy.

p38丝裂原活化蛋白激酶(p38 MAPK)最早因为与应激相关而引起注意,近来发现它在多种 肿瘤 ，包括 宫颈癌, 卵巢癌, 肝癌, 淋巴瘤 中,与 凋亡 的启动、 细胞周期 的静止等密切相关,并且具有细胞特异性,在不同 肿瘤细胞 作用并不相同,甚至起了完全相反的作用。

目前认为p38 MAPK促进细胞凋亡的机制是通过磷酸化P53、诱导Bax转位、增强c-myc的表达、参与Fas/FasI介导的凋亡、增强TNF-d表达、激活c-jun和c-fos等多种途径, 诱导细胞凋亡的[1]。

Phospho-p38 MAPK (Thr180/Tyr182) Antibody detects endogenous levels of p38 MAPK only when activated by phosphorylation at threonine 180 and tyrosine 182. This antibody does not cross-react with the phosphorylated forms of either p42/44 MAPK or SAPK/JNK.

Interactive p38 MAPK pathway. Learn how p38 MAPK is involved in regulation of HSP27, MAPKAPK-2, MAPKAPK-3, & several transcription factors.

The mitogen-activated protein kinase (MAPK) p38 is an essential family of kinases, regulating responses to environmental stress and inflammation. There is an ever-increasing plethora of physiological and pathophysiological conditions attributed to ...

In this review, we provide an extensive description of the main biological functions of p38 and focus on recent studies that have addressed its role in cancer. Furthermore, we provide an updated overview of therapeutic strategies targeting p38 in cancer and promising alternatives currently being explored.

2003年9月1日 · Four homologues/isoforms of p38 MAPK have been identified: p38α, p38β, p38γ and p38δ. Of these, p38α is the best characterized and perhaps the most physiologically relevant kinase involved in...

2023年6月12日 · Here, we report the in silico identification of compounds that we refer to as non-canonical p38α inhibitors (NC-p38i). By combining biochemical and structural analyses, we show that NC-p38i...