The p38 Pathway: From Biology to Cancer Therapy - PMC
In this review, we provide an extensive description of the main biological functions of p38 and focus on recent studies that have addressed its role in cancer. Furthermore, we provide an …
p38 MAPK 通路 | Cell Signaling Technology
mapkkk 磷酸化并激活 mkk3/6，后者即是 p38 mapk 激酶。mkk3/6 也可在凋亡因素的刺激下直接由 ask1 激活。p38 mapk 参与调节 hsp27、mapkapk-2 (mk2)、mapkapk-3 (mk3) 和其他几 …
热门靶点p38 MAPK - 知乎 - 知乎专栏
p38 MAPK 参与调节 HSP27、 MAPKAPK-2 (MK2)、 MAPKAPK-3 (MK3) 和其他几种转录因子，包括 ATF-2 、 Stat1 、 Max/Myc 复合体 、 MEF-2 和 Elk-1，而 CREB 通过激活 MSK1 间 …
p38 MAPK调控酶及转录因子 | MCE - 健康界
2022年8月3日 · 在 lps 处理的巨噬细胞中，sb 202190 通过抑制 p38 mapk 通路下游特异性底物 mk2 磷酸化，从而影响 hsp27 活化。 但与 SB 203580 有所不同，在某些情况下，SB 202190 …
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
2007年4月10日 · p38 MAPK and MAPK-activated protein kinase 2 (MK2) are key components of signaling pathways leading to many cellular responses, notably the proinflammatory cytokine …
The p38 MAPK -MK2 Signaling Axis as a Critical Link Between ... - PubMed
2021年1月28日 · We propose that neuronal MK2 may be an important player in the link between inflammatory states and dysregulation of synaptic plasticity underlying cognitive functions. …
Human Gene Set: PID_P38_MK2_PATHWAY - GSEA-MSigDB
Filtered by similarity ? Compute overlaps ? Compendia expression profiles ? Gene families ? See MSigDB license terms here. Please note that certain gene sets have special access terms.
Frontiers | The p38MAPK-MK2 Signaling Axis as a Critical Link …
2021年1月27日 · p38 is a mitogen-activated protein kinase (MAPK), that responds primarily to stress stimuli. p38 has a number of targets for phosphorylation, including MAPK-activated …
An overview of mammalian p38 mitogen-activated protein kinases, central ...
Via MK2/MK3, p38 also upregulates cytokine mRNA transcription by the serum response transcription factor (SRF) 189, and similarly, via MK2/MK3, p38 regulates mRNA stability by …
MAPKAPK2: the master regulator of RNA-binding proteins …
2019年3月8日 · The stress-activated p38MAPK signaling pathway regulates a plethora of cellular processes in particular apoptosis, cell division, cell invasion, and inflammatory response . …