卵圆细胞（oval cell）是2014年公布的组织学与胚胎学名词，出自《组织学与胚胎学名词》第二版。 位于肝门管区一带的小而圆的细胞。 具有干细胞性质。 《组织学与胚胎学名词》第二版。 [1] 卵圆细胞（oval cell）是2014年公布的组织学与胚胎学名词，出自《组织学与胚胎学名词》第二版。

Transplantation and repopulation experiments have demonstrated that hepatocytes, which are highly differentiated and long-lived cells, have a remarkable capacity for multiple rounds of replication. In this article, we review some aspects of the regulation of hepatocyte proliferation as well as the interrelationships between hepatocytes and oval ...

Oval cells are a specific type of cells with oval shaped nucleus that appear in the injured liver when hepatocyte proliferation is inhibited by toxins or genetic changes. It is not clear with regard to the cell origin of oval cells. 2AAF(N-acetylaminofluorene)/PHx inhibits hepatocyte proliferation and induces oval cell activation in a rat model ...

2024年6月3日 · Oval cell hyperplasia (Figure 1) is rarely seen in control animals. It typically begins either in periportal areas or in subcapsular regions of the liver. The proliferating oval cells are spindloid and initially extend out from portal areas in a linear array; they may encircle hepatic lobules, and in severe cases they may form irregular solid ...

2003年1月1日 · These stem cells can generate small round cells referred to as oval cells which express markers of both fetal hepatocytes and biliary cells (Hixson et al., 1992) and are capable of generating hepatocytes and bile duct cells. Because of these properties oval cells are considered to be bipotential progenitor cells in adult livers.

Oval cell hyperplasia is typically seen in livers with multiple toxic changes as a result of treatment or infection as well as in mice treated with some hepatocarcinogens. Oval cells are small spindloid, oval, or round cells with scant cytoplasm. They usually appear initially in periportal and subcapsular areas.

The extensively characterized rat hepatic stem/progenitor cell, or oval cell, has been demonstrated by our laboratory, as well as several others, to show particular promise as a tool for the treatment of genetic liver disorders and as a bridging therapy or alternative to …

2022年2月2日 · Following studies characterized oval cells as hyperplastic epithelial cells with small cellular size, a high nuclear/plasma ratio and expression of the hepatoblast marker alpha-fetoprotein (AFP). 8 - 11 Oval cells were considered to be bipotential progenitor cells as they showed the capacity to differentiate into hepatocytes and bile duct cells ...

2018年11月29日 · While the oval cell response has been captured in vitro by growing organoids from cholangiocytes, the hepatocyte proliferative response has not been recapitulated in culture. Here, we describe the establishment of a long-term 3D organoid culture system for mouse and human primary hepatocytes.

Hepatic oval cells (HOCs) are recognized as facultative liver progenitor cells that play a role in liver regeneration after acute liver injury. Here, we investigated the in vitro proliferation and differentiation characteristics of HOCs in order to ...