There are studies in osteosarcoma patients which describe a better local control with amputation but no survival benefit over LSS in patients with intralesional or marginal margins but also two meta analyses showing higher five-year survival rates for LSS [10,11].

Among patients in the NCDB, amputation for osteosarcoma is associated with advanced age, advanced stage, larger tumors, greater comorbidities, and lower income. Limb salvage is associated with a significant survival benefit, even when controlling for significant confounding variables and differences between cohorts.

With proper physical therapy, a person is often able to walk on his/her own 3 to 6 months after a leg amputation. If the osteosarcoma is in the shoulder or upper arm and amputation is needed, in some cases the area with the tumor can be removed and the lower arm reattached so that the patient has a functional, but much shorter, arm.

Over the last four and half decades, the world has seen the journey of osteosarcoma from amputation to limb salvage and long term survival rate has risen up to 80% with localized disease. 1, 3 Limb salvage refers to successful to safe margin resection of a tumor and reconstruction of a viable, functional extremity. 1

Jan 5, 2021 · A poor response to chemotherapy (≤ 90% necrosis) for osteosarcomas leads to poorer survival and an increased risk of local recurrence, particularly if there is a close margin of excision. We evaluated whether amputation confers any survival benefit over limb salvage surgery (LSS) with narrow margins …

It appears that, compared with above-the-knee amputation or disarticulation of the hip, the use of a limb-salvage procedure for osteosarcoma of the distal end of the femur did not shorten the disease-free interval or compromise long-term survival.

Nov 24, 2023 · In young patients less than 8 years of age with bone sarcoma, standard means of reconstruction carry a higher risk of profound limb length discrepancy in the operated limb. In these difficult cases, amputation may offer the best long-term outcomes [11].

Mar 1, 2016 · Osteosarcoma is an aggressive malignant neoplasm, and conflicting findings have been reported on the survival and function recovery in osteosarcoma patients experiencing limb salvage or amputation. In the present study, we compared clinical outcomes regarding limb salvage surgery vs. amputation for osteosarcoma patients by a meta-analysis.

Introduction: To perform a meta-analysis for comparing the functional outcomes and quality of life (QOL) of osteosarcoma patients receiving amputation or limb-salvage surgeries. Materials and methods: A search was conducted of the Medline, Cochrane, EMBASE, and Google Scholar on September 30, 2013.

Oct 14, 2020 · Among patients in the NCDB, amputation for osteosarcoma is associated with advanced age, advanced stage, larger tumors, greater comorbidities, and lower income. Limb salvage is associated with a significant survival benefit, even when controlling for significant confounding variables and differences between cohorts.