奥沙拉嗪别名奥柳氮(Olsalazine)是两分子的5-ASA偶合而成，疗效与SASP相似，zinberg等以3g/d用于轻中度病人改善率达51%。 Eve等研究表明奥柳氮全身吸收较包裹的mesalazine少，副作用低。

Olsalazine is an anti-inflammatory medication used in the treatment of ulcerative colitis. [2] [3] It is sold under the brand name Dipentum. [4] Olsalazine itself is a pro-drug of mesalazine (5-aminosalicyclic acid or 5-ASA) and is not absorbed in the small intestine.

2024年12月10日 · Olsalazine is used to treat ulcerative colitis in adults. Olsalazine may also be used for purposes not listed in this medication guide.

2025年2月1日 · Olsalazine is used in patients who have had ulcerative colitis to prevent the condition from occurring again. It works inside the bowel by helping to reduce inflammation and other symptoms of the disease.

Olsalazine is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum) in adults when another medication (sulfasalazine) could not be tolerated. Olsalazine is in a class of medications called anti-inflammatory agents.

Olsalazine is an anti-inflammatory agent that blocks the production of cyclooxygenase (COX)-derived products of arachidonic acid metabolism. 5 It works to alleviate inflammation in ulcerative colitis. 1. Olsalazine was shown to decrease water and sodium absorption.

2024年12月15日 · Dipentum (olsalazine) is commonly used to treat ulcerative colitis, which is an inflammatory bowel condition that affects your large intestine. Dipentum may also be used for other conditions as...

2023年9月20日 · What is olsalazine, and what is it used for? Olsalazine is an oral medication that works as an anti-inflammatory drug for treating inflammatory diseases of the colon such as ulcerative colitis (UC). It is a derivative of salicylic acid. Inactive itself, it is converted by the bacteria in the colon to its active form, mesalamine.

Olsalazine is an anti-inflammatory agent that blocks the production of cyclooxygenase (COX)-derived products of arachidonic acid metabolism. It works to alleviate inflammation in ulcerative colitis. Olsalazine was shown to decrease water and sodium absorption.

本品以活性成分5一氨基水杨酸替代柳氮磺胺吡啶中无活性的磺胺吡啶，即通过偶氮键连接两分子5一氨基水杨酸，提高了疗效，降低了不良反应发生率。 5一氨基水杨酸后在小肠被吸收，乙酰化后随尿排出，不能到达结肠部位，本品在胃及小肠中不被吸收也不分解，到达结肠部位后其偶氮桥在细菌作用下断裂，分解为二分子5一氨基水杨酸并作用于结肠炎症粘膜，抑制前列腺素合成，抑制炎症介质白三烯的形成，降低肠壁细胞膜的通透性，减轻肠粘膜水肿。 本品以活性成分5一氨 …