OMA1 - Wikipedia
Metalloendopeptidase OMA1, mitochondrial is an enzyme that in humans is encoded by the OMA1 gene. [5][6] OMA1 is a Zn 2+ -dependent metalloendopeptidase in the inner membrane …
Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar Structure ...
Fusion of the inner membrane, mediated by optic atrophy-1 (OPA1), is a stress-sensitive mechanism of mitochondrial dynamic homeostasis, controlled by the OMA1 metalloprotease. …
OMA1 Gene - GeneCards | OMA1 Protein | OMA1 Antibody
2025年3月30日 · OMA1 (OMA1 Zinc Metallopeptidase) is a Protein Coding gene. Diseases associated with OMA1 include Snail Allergy and Optic Atrophy 11 . Among its related …
OMA1 reprograms metabolism under hypoxia to promote …
2020年12月13日 · OMA1 knockout suppresses colorectal cancer development in AOM/DSS and xenograft mice models of colorectal cancer. OMA1‐OPA1 axis is activated by hypoxia, …
OMA1—an integral membrane protease? - PMC - PubMed …
OMA1 is a mitochondrial protease. Among its substrates are DELE1, a signaling peptide, which can elicit the integrated stress response, as well as the membrane-shaping dynamin-related …
Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure ...
2021年2月19日 · In the present study, we show that in addition to its role in mitochondrial fission, OMA1 is required for the organelle's ultrastructural organization through its association with …
Prohibitin levels regulate OMA1 activity and turnover in neurons
2019年12月9日 · Here, we investigate the effects of modulating neuronal PHB levels on OMA1 stability and OPA1 cleavage. We demonstrate that PHB promotes OMA1 turnover, effectively …
The mitochondrial protease OMA1 acts as a metabolic safeguard …
2023年4月25日 · The peptidase OMA1 regulates mitochondrial morphology via OPA1 and stress signaling via DELE1 and orchestrates tumorigenesis and cell survival in a cell- and tissue …
Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic
2015年9月14日 · Here, we show that the IMQC protease Oma1 is required for the stability of the respiratory supercomplexes and thus balanced and tunable bioenergetic function.
OMA1-Mediated Mitochondrial Dynamics Balance Organellar
2024年4月22日 · OMA1 is a unique regulator of stress-sensitive homeostatic mitochondrial balance, acting as a key upstream sensor capable of priming the cell for apoptosis, autophagy, …
The mitochondrial protease OMA1 acts as a metabolic safeguard …
2023年3月31日 · Here, we use unbiased systems-based approaches to show that OMA1-dependent cell survival depends on metabolic cues. A metabolism-focused CRISPR screen …
Increased Mobile Zinc Regulates Retinal Ganglion Cell Survival via ...
Here, we show that increased levels of Zn 2+ upregulate the expression and activity of mitochondrial zinc metallopeptidase OMA1 in the retina, leading to the cleavage of DELE1 and …
Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1
2018年5月10日 · Subsequently, Optic atrophy 1 (OPA1), a mitochondrial inner membrane protein that regulates fusion and cristae structure, was significantly elevated in the hMSCs-Lep pre …
Recent advances in, and challenges of, designing OMA1 drug …
2022年2月1日 · OMA1, OPA1 and Luke-S1 reporter protein turnover in Western blots. OMA1 is activated within minutes upon exposure of HEK293T cells to 2 µM CCCP (A) or 100 nM …
OMA1—An integral membrane protease? - ScienceDirect
2021年2月1日 · OMA1 is a mitochondrial protease. Among its substrates are DELE1, a signaling peptide, which can elicit the integrated stress response, as well as the membrane-shaping …
dase OMA1 regulates mitochondrial morphology via OPA1 and stress signaling via DELE1 and orchestrates tumorigenesis and cell survival in a cell- and tissue-specific manner. Here, we …
OMA1 reprograms metabolism under hypoxia to promote …
2021年1月1日 · OMA1 knockout suppresses colorectal cancer development in AOM/DSS and xenograft mice models of colorectal cancer. OMA1‐OPA1 axis is activated by hypoxia, …
Stress-induced OMA1 activation and autocatalytic turnover …
2014年3月3日 · OMA1 is constitutively active but displays strongly enhanced activity in response to various stress insults. We identify an amino terminal stress-sensor domain of OMA1, which …
p32/C1QBP regulates OMA1-dependent proteolytic processing …
2020年6月30日 · Here, we demonstrated the role of p32/C1QBP in mitochondrial morphology by regulating OMA1-dependent proteolytic processing of OPA1. Genetic ablation of p32/C1QBP …
EGCG protects cardiomyocytes against hypoxia-reperfusion injury …
2019年1月25日 · OMA1, a metalloendopeptidase, initiates the proteolytic process of the fusion-allowing protein OPA1, to deteriorate mitochondrial structure and function.