Anti-CD8α Antibody (OKT-8) is a kind of mouse IgG2a chimeric antibody, targeting to human CD8α. The recommend isotype control of Anti-CD8α Antibody (OKT-8): Mouse IgG2a kappa, Isotype Control ( HY-P99978 ).

In contrast, one anti-human CD8 antibody, OKT8, induced effector function in all CD8 + T-cells examined. Moreover, OKT8 was found to enhance TCR/pMHCI on-rates and, as a consequence, could be used to improve pMHCI tetramer staining and the …

2022年11月8日 · An OKT8 antibody that binds human CD8 (BD Biosciences, NJ) served as a positive control. For FACS binding experiments with primary cells, the antibodies (VHH5, OKT8, and isotype control) were directly labeled with Alexa Fluor™ 647 NHS Ester according to the manufacturer’s protocol (Thermo Fisher Scientific, MA).

2003年12月15日 · First, recent surface plasmon resonance (SPR) data show that TCR binding to a pMHCII ligand is kinetically distinct from and independent of CD4 (14). Second, studies with altered peptide ligands suggest that the CD4 coreceptor binds sequentially to pMHCII provided the initial TCR/pMHCII interaction is of sufficient duration (15).

2011年7月15日 · Six of seven anti-human CD8 Abs tested did not activate CD8 + T cells. In contrast, one anti-human CD8 Ab, OKT8, induced effector function in all CD8 + T cells examined. Moreover, OKT8 was found to enhance TCR/pMHCI on-rates and, as a consequence, could be used to improve pMHCI tetramer staining and the visualization of Ag-specific CD8 + T cells.

Invitrogen Anti-CD8a Monoclonal (OKT8 (OKT-8)), eBioscience™, Catalog # 14-0086-80. Tested in Flow Cytometry (Flow) applications. This antibody reacts with Human samples. Supplied as 25 µg purified antibody (0.5 mg/mL).

violetFluor™ 450 Mouse monoclonal [OKT8] to CD8 alpha; Suitable for: Flow Cyt; Reacts with: Human; Conjugation: violetFluor™ 450. Ex: 405nm, Em: 450nm; Isotype: IgG2a; 你可能会感兴趣

CD8也称为T8或Leu2，是免疫球蛋白超家族的一员，表达于大部分胸腺细胞、外周血T细胞亚群和NK细胞 (基本为CD8α/α同源二聚体)。 CD8在抗原识别和T细胞活化中，作为MHC I类分子受限的T细胞受体，并在胸腺分化中具有重要作用。 Enables MHC class I protein complex binding activity. Predicted to be involved in T cell mediated immunity; cell surface receptor signaling pathway; and cytotoxic T cell differentiation.

Description: The OKT8 monoclonal antibody reacts with the human CD8a molecule, an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha beta) or as a homodimer (CD8 alphaalpha).

Invitrogen Anti-CD8a Monoclonal (OKT8 (OKT-8)), eBioscience™, Catalog # 16-0086-85. Tested in Flow Cytometry (Flow), Control (Ctrl) and Functional Assay (Functional) applications. This antibody reacts with Human samples. Supplied as 500 µg purified antibody (1 mg/mL).