Occludin was initially postulated to be an essential tight junction component, but this idea was discarded due to the presence of tight junctions within occludin gene (Ocln) knockout …

Occludin is a 65-kDa phosphoprotein that is an integral component of tight junctions. It plays a crucial role in forming the paracellular barrier between neighboring cells and is associated with …

2005年4月25日 · The structure of occludin, including its gene splice variants and protein essential components have been elucidated. Phosphorylation/dephosphorylation plays a major role in …

2023年2月18日 · Occludin, the first transmembrane protein identified in TJs, has received intense research interest because numerous in vitro studies have suggested its importance in …

2005年4月25日 · Strategies to prevent and/or reverse occludin downregulation may be an important therapeutic target. 1. Introduction and discovery. Tight junctions, adherens junctions, …

2007年7月13日 · Occludin is a 65 kD transmembrane protein localized to TJs which anchors ZO-1 and ZO-2 proteins and the plasma membranes of adjacent cells . Occludin is present in large …

Occludin, a 65-kDa tetraspan integral membrane protein, contributes to TJ stabilization and optimal barrier function.

2019年1月3日 · Promoter analysis revealed that occludin enhances CASP3 transcription and, conversely, that occludin downregulation reduces caspase-3 expression.

2010年1月19日 · Occludin, the first identified integral TJ protein, is a ∼60 kDa tetraspan membrane protein that forms two extracellular loops flanked by cytoplasmic N and C termini.

Occludin knock down causes an increase in paracellular flux of macromolecules. In the following studies, the effect of occludin depletion on transepithelial permeation of increasing molecular …