Synthetic analogues of 2-oxo acids discriminate metabolic
2020年2月5日 · Using succinyl, glutaryl and adipoyl phosphonates on the enzyme preparations from tissues with varied DHTKD1 expression reveals the contributions of OADH and OGDH to …
2-氧代己二酸脱氢酶抑制对大鼠脑代谢的延迟影响与蛋白质戊二酰 …
使用 OADH 的药理抑制作用和脊髓损伤 (SCI) 的动物模型，我们探讨了这一假设。 SCI 的体重下降模型、OADH 定向抑制剂三甲基己二酰膦酸酯 (TMAP) 的单次鼻内给药以及大鼠脑中相关代 …
Delayed Impact of 2-Oxoadipate Dehydrogenase Inhibition on the …
2022年5月31日 · We hypothesize that systemic significance of OADH relies on its generation of glutaryl residues for protein glutarylation. Using pharmacological inhibition of OADH and the …
Functional Versatility of the Human 2-Oxoadipate Dehydrogenase …
2022年7月26日 · The results demonstrate that E1a oxidizes a non-cognate substrate 2-oxopimelate (OP) as well as OA through the decarboxylation step, but the OADHc was 100 …
Administration of Phosphonate Inhibitors of Dehydrogenases of 2 ...
The DHTKD1-encoded 2-oxoadipate dehydrogenase (OADH) is a member of the family of the thiamine-diphosphate-dependent dehydrogenases of 2-oxo acids, whose well-known …
Selective Inhibition of 2-Oxoglutarate and 2-Oxoadipate …
The present work develops application of this class of compounds to specific in vivo inhibition of 2-oxoglutarate dehydrogenase (OGDH) and its isoenzyme, 2-oxoadipate dehydrogenase …
Administration of Phosphonate Inhibitors of Dehydrogenases of 2 ...
2022年6月20日 · In vitro and in cell cultures, succinyl phosphonate (SP) and adipoyl phosphonate (AP) selectively target dehydrogenases of 2-oxoglutarate (OGDH, encoded by …
Isoforms of the DHTKD1-Encoded 2-Oxoadipate Dehydrogenase ... - PubMed
This study aims at molecular characterization of OADH from animal tissues. Phylogenetic analysis of 2-oxo acid dehydrogenases reveals OADH only in animals and Dictyostelium discoideum …
Delayed Impact of 2-Oxoadipate Dehydrogenase Inhibition on the …
2022年6月1日 · The proportionality suggests autoglutarylation of OADH, supported by our mass-spectrometric identification of glutarylated K155 and K818 in recombinant human OADH. In …
(PDF) Vitamin-Dependent Multienzyme Complexes of 2-Oxo Acid ...
2017年6月1日 · These are mutations in the DHTKD1 and PDK3 genes encoding the mitochondrial enzymes 2-oxoadipate dehydrogenase (OADH) and the neural-tissue-specific isoenzyme 3 of …