In this review, we critically examine the relationship between obesity and the brain. We emphasise obesity-related cognitive impairment and dementia, but we also address the more subtle changes in brain structure and functioning in obesity. We also discuss pre-clinical studies and epidemiological studies that reveal the biological mechanisms ...

2025年3月3日 · This study utilized comprehensive obesity measures to identify five obesity trajectories and elucidate the relationships between long-term obesity changes and brain health and cognition.

2024年5月28日 · Associations between brain and obesity are bidirectional: changes in brain structure and function underpin over-eating, while chronic adiposity leads to brain atrophy. Investigating...

2020年5月28日 · Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between obesity and brain structure using structural MRI (n =...

2023年6月12日 · Obesity may damage the brain’s ability to recognize the sensation of fullness and be satisfied after eating fats and sugars, a new study found.

Obesity-related structural changes in the brain can explain poor cognitive performance of overweight and obese individuals [53, 85, 106]. Beyer et al. [ 106 ] demonstrated that high body fat, visceral adiposity, and systemic inflammation are associated with reduced gray matter volume and executive functions.

2024年4月27日 · Obesity, a burgeoning global health issue, is increasingly recognized for its detrimental effects on the central nervous system, particularly concerning the integrity of the blood-brain barrier (BBB).

We conduct a detailed examination of recent genetic findings, correlating them with clinical and behavioral phenotypes associated with obesity. This includes how polygenic obesity, influenced by a myriad of genetic variants, impacts brain regions associated with addiction and reward, differentiating it from monogenic forms.

To investigate the impact of obesity on brain structure and cognition using large neuroimaging and genetic data. Associations between body mass index (BMI), gray matter volume (GMV), whiter matter hyper-intensities (WMH), and fluid intelligence score (FIS) were estimated in 30283 participants from the UK Biobank.

Obesity is therefore associated with detectable brain volume deficits in cognitively normal elderly subjects. Obesity is associated with increased risk for cardiovascular health problems including diabetes, hypertension, and stroke.