The ob/ob or obese mouse is a mutant mouse that eats excessively due to mutations in the gene responsible for the production of leptin and becomes profoundly obese. It is an animal model of type II diabetes .

ob是瘦素的编码基因，利用EGE技术将ob基因2、3号外显子敲除制备的B-ob/ob小鼠，具有肥胖症和高血糖症状，是研究高血糖和肥胖症的有力模型。 三、特点 Ob/ob mouse 是一种突变小鼠，过量进食，导致非常肥胖。

2016年8月10日 · Ob/ob mouse 是一种突变小鼠，过量进食，导致非常肥胖。 它是一种2型糖尿病模型。 突变基因ob的证明使我们发现了瘦素，其对食欲的控制很重要。 第一只Ob/ob mouse 是在1949年Jackson 实验室做克隆实验时偶然发现的，属于隐形突变。 突变小鼠刚出生时在形态上与那些没受到影响的小鼠没有不同，但是在生长过程中体重增加得很快，是未突变小鼠的三倍。 突变小鼠的胰岛细胞增加扩大，胰岛素水平提高，但任然会发展得高血糖。 突变的ob基因用定点克 …

ob/ob mouse. The ob/ob leptin-deficient mouse spontaneously develops obesity and type 2 diabetes secondary to hyperphagia, hyperglycemia, and hyperinsulinemia (168,169). These mice are indistinguishable from their lean littermates (ob/+) at birth, but within 2 weeks gain weight and are hyperinsulinemic.

000632 B6.Cg- Lep ob /J Mice homozygous for the obese spontaneous mutation, Lep ob (commonly referred to as ob or ob/ob ), exhibit obesity, hyperphagia, transient hyperglycemia, glucose intolerance, and elevated plasma insulin. They …

This study was aimed at characterization of PDN in leptin-deficient (ob/ob) mice, a model of type 2 diabetes with relatively mild hyperglycemia and obesity. ob/ob mice ( approximately 11 weeks old) clearly developed manifest sciatic motor nerve conduction velocity (MNCV) and hind-limb digital sensory nerve conduction velocity (SNCV) deficits ...

Leptin-deficient ob/ob mice were injected with mouse embryonic fibroblasts, which formed adipose tissue in vivo and prevented the metabolic abnormalities of leptin deficiency. Metabolic syndrome is a global epidemic that consists of multiple risk factors including central obesity and insulin resistance.

ob是瘦素的编码基因，利用EGE技术将ob基因2、3号外显子敲除制备的B-ob/ob小鼠，具有肥胖症和高血糖症状，是研究高血糖和肥胖症的有力模型。 三、特点 Ob/ob mouse 是一种突变小鼠，过量进食，导致非常肥胖。

纯合的 Lepob突变 小鼠（ob/ob）和 Leprdb突变 小鼠（db/db）是最早的糖尿病小鼠模型，目前仍然是糖尿病研究的热门选择。对这两种小鼠，糖尿病发生发展的严重程度受到其品系遗传背景的影响，简要的对比如下所示。

Subsequently, two strains of obese mutants, the ob/ob mouse and later the db/db mouse, were discovered 50 and 40 years ago, respectively, and proved invaluable to studying the regulation of food intake, energy expenditure and obesity. Prior to the development of today’s more sophisticated techniques for studying biological and biochemical ...