ob/ob mouse - Wikipedia
The ob/ob or obese mouse is a mutant mouse that eats excessively due to mutations in the gene responsible for the production of leptin and becomes profoundly obese. It is an animal model of type II diabetes .
OB/OB MICE（肥胖鼠）—— Ⅱ型糖尿病 - 知乎 - 知乎专栏
ob是瘦素的编码基因，利用EGE技术将ob基因2、3号外显子敲除制备的B-ob/ob小鼠，具有肥胖症和高血糖症状，是研究高血糖和肥胖症的有力模型。 三、特点 Ob/ob mouse 是一种突变小鼠，过量进食，导致非常肥胖。
ob/ob mice and db/db mice - 知乎 - 知乎专栏
2016年8月10日 · Ob/ob mouse 是一种突变小鼠，过量进食，导致非常肥胖。 它是一种2型糖尿病模型。 突变基因ob的证明使我们发现了瘦素，其对食欲的控制很重要。 第一只Ob/ob mouse 是在1949年Jackson 实验室做克隆实验时偶然发现的，属于隐形突变。 突变小鼠刚出生时在形态上与那些没受到影响的小鼠没有不同，但是在生长过程中体重增加得很快，是未突变小鼠的三倍。 突变小鼠的胰岛细胞增加扩大，胰岛素水平提高，但任然会发展得高血糖。 突变的ob基因用定点克 …
000632 - B6 ob Strain Details - The Jackson Laboratory
000632 B6.Cg- Lep ob /J Mice homozygous for the obese spontaneous mutation, Lep ob (commonly referred to as ob or ob/ob ), exhibit obesity, hyperphagia, transient hyperglycemia, glucose intolerance, and elevated plasma insulin. They …
obob 小鼠和 dbdb 小鼠 - 知乎 - 知乎专栏
ob是瘦素的编码基因，利用EGE技术将ob基因2、3号外显子敲除制备的B-ob/ob小鼠，具有肥胖症和高血糖症状，是研究高血糖和肥胖症的有力模型。 三、特点 Ob/ob mouse 是一种突变小鼠，过量进食，导致非常肥胖。
Mouse Embryonic Fibroblasts Protect ob/ob Mice From Obesity …
We performed a single subcutaneous injection of MEFs into leptin-deficient ob/ob mice. The MEF injection formed a single fat pad that is histologically similar to white adipose tissue. The ob/ob mice receiving MEFs (obRs) had significantly lower BW compared with nontreated ob/ob mice, primarily because of decreased adipose tissue mass.
The leptin-deficient (ob/ob) mouse: a new animal model of ... - PubMed
This study was aimed at characterization of PDN in leptin-deficient (ob/ob) mice, a model of type 2 diabetes with relatively mild hyperglycemia and obesity. ob/ob mice ( approximately 11 weeks old) clearly developed manifest sciatic motor nerve conduction velocity (MNCV) and hind-limb digital sensory nerve conduction velocity (SNCV) deficits ...
原 】 ob/ob和db/db大小鼠详细介绍 - 360doc
2021年3月18日 · Leptin为肥胖基因（ob）编码产物，是脂肪细胞分泌的蛋白质类激素，在调节能量平衡、摄食行为起重要作用。 若ob基因突变，食欲大增，体重剧增，产生严重的肥胖特征，多用于肥胖症的研究。
Ob/Ob Mouse - an overview | ScienceDirect Topics
The obese diabetic mouse (ob/ob) is an excellent model for the study of obesity and diabetes as it has a longer lifespan and less severe clinical symptoms than the diabetic mouse (db/db).
ob/ob Mice are well suited for studies on the interaction between leptin and insulin, and for studies on initial aspects of metabolic disturbances leading to type-2diabetes. KEYWORDS: obese hyperglycemic, mice, leptin, pancreatic islets, insulin resistance, immunity, and reproduction INTRODUCTION