2024年12月29日 · The +1 PRF of OAZ1 mRNA is stimulated by polyamines, serving as a critical feedback mechanism in polyamine synthesis regulation. When polyamine levels are elevated, the +1 PRF results in the expression of full-length OAZ1, which inhibits ODC and extracellular polyamine uptake [ 29 ].

Ornithine decarboxylase antizyme is an enzyme that in humans is encoded by the OAZ1 gene. [5] [6] [7] Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by ...

6 天之前 · OAZ1 (Ornithine Decarboxylase Antizyme 1) is a Protein Coding gene. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and DREAM Repression and Dynorphin Expression. Gene Ontology (GO) annotations related to this gene include enzyme inhibitor activity and ornithine decarboxylase inhibitor activity.

2020年6月16日 · Programmed ribosomal frameshifting (PRF) is the controlled slippage of the translating ribosome to an alternative frame. This process is widely employed by human...

Results show that ornithine decarboxylase antizyme 1 (OAZ1) simultaneously inhibits the proliferation and induces the differentiation of oral cancer cells. To further understand its functions in CML pathogenesis, OAZ1 was overexpressed, and PCR array analysis was used to monitor the expression of key genes commonly involved in leukemia development.

2011年9月7日 · Here we used S. cerevisiae OAZ1 to dissect the enigmatic mechanism underlying polyamine regulation of RFS. In contrast with previous assumptions, we report here that the nascent antizyme...

2021年11月30日 · PRF 信号是嵌入在 mRNAs 中的顺式作用元件，随机地将核糖体翻译到一个新的阅读框中（即 +1 或 − 1 核苷酸）。 在典型的病毒环境中，PRF 信号允许核糖体绕过框终止密码子中编码的 0-框，继续合成 C-末端延伸的融合蛋白。

2018年9月20日 · The stop codon of OAZ1, serving as the +1 PRF site, appears to be a dividing point for “sticky” codon composition in frame 2. Since frame 2 becomes frame 1 after +1 PRF, this result supports the view that codon optimization is highly coordinated between general coding regions and specific PRF signals.

2024年2月22日 · PRFect combines advanced machine learning techniques with the integration of multiple complex cellular properties, such as secondary structure, codon usage, ribosomal binding site interference, direction, and slippery site motif.

Silencing OAZ1 caused an increase of the ornithine decarboxylase enzyme and the cellular levels of putrescine and spermidine; an indication that increased cellular polyamines enhances luciferase expression without affecting its transcription. The study shows that OAZ1 is a novel target for improving expression of recombinant proteins.