2020年6月16日 · Programmed ribosomal frameshifting (PRF) is the controlled slippage of the translating ribosome to an alternative frame. This process is widely employed by human...

2021年11月30日 · PRF 信号是嵌入在 mRNAs 中的顺式作用元件，随机地将核糖体翻译到一个新的阅读框中（即 +1 或 − 1 核苷酸）。 在典型的病毒环境中，PRF 信号允许核糖体绕过框终 …

2019年5月10日 · Ornithine decarboxylase (ODC), a key enzyme in this process, is degraded by ornithine decarboxylase antizyme (OAZ). Synthesis of OAZ requires a +1 PRF event that is …

2006年7月12日 · A similar shifty stop +1 frameshift in the ornithine decarboxylase antizyme (OAZ) of eukaryotes provides a method of feedback regulation in response to downstream metabolic …

PRF reportedly regulates the expression of release factor 2 (RF2) 12,13; in fungi and mammals, + 1 PRF purportedly regulates the expression of ornithine decarboxylase antizyme (OAZ), the...

2016年2月19日 · Programmed −1 ribosomal frameshifting (−1 PRF) has been identified as a mechanism to regulate the expression of many viral genes and some cellular genes. The …

2024年2月1日 · Down-regulation of the titration of OAZ via AZIN leads to enhanced degradation of OAZ-targeted ODC, reducing ODC, inhibiting putrescine synthesis, and suppressing further …

PRFect combines advanced machine learning techniques with the integration of multiple complex cellular properties, such as secondary structure, codon usage, ribosomal binding site …

2005年12月23日 · The impact of polyamines on translation is highlighted by autoregulation of the translation of mRNAs encoding key metabolic and regulatory proteins in the polyamine …

2011年9月7日 · Ornithine decarboxylase (ODC), the rate-limiting enzyme in the biosynthesis of polyamines, is regulated by an antizyme (OAZ). Polyamines induce antizyme expression by …