For over five decades, Orthopaedic Associates of Zanesville has been the trusted provider of orthopaedic care in Zanesville and its surrounding areas. Established in 1969, our practice has remained committed to delivering individualized, compassionate care to every patient who walks through our doors.

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OAZ may refer to: . OAZ1, ornithine decarboxylase antizyme, an enzyme that in humans is encoded by the OAZ1 gene; OAZ2, ornithine decarboxylase antizyme 2, an enzyme that in humans is encoded by the OAZ2 gene; Outer Artillery Zone, a narrow belt along the coast from Suffolk to Sussex in the Air Defence of Great Britain

Our highly skilled team of board certified physicians, physician assistants, clinical staff, physical therapists, and clerical staff is dedicated to providing you with the highest quality of professional diagnosis, treatments, and care. Our team offers surgical, non-surgical, and outpatient services.

2011年9月7日 · Regulation of polyamine synthesis is mainly achieved by controlling the activity of ornithine decarboxylase (ODC) through an unusual mechanism involving ODC antizyme 1, 4, the binding of which...

2025年3月30日 · OAZ1 (Ornithine Decarboxylase Antizyme 1) is a Protein Coding gene. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and DREAM Repression and Dynorphin Expression. Gene Ontology (GO) annotations related to this gene include enzyme inhibitor activity and ornithine decarboxylase inhibitor activity.

该基因编码抗酶 1，它是抗酶家族的第一个成员，具有广泛的组织分布，并通过结合并靶向 ODC 进行降解以及抑制多胺摄取来负向调节细胞内多胺水平。 抗酶 1 mRNA 包含两个潜在的框内 AUG；在大鼠中进行的研究表明，交替使用两个翻译起始位点会导致 N 末端不同的蛋白质同种型具有不同的亚细胞定位。 还注意到该基因的可变剪接转录物变体。 [RefSeq 提供，2014 年 12 月]

We investigated the role of the transcriptional activator and Smad1/4 cofactor OAZ in regulating bone morphogenetic protein (BMP) signaling. We demonstrate that upon BMP4 stimulation, an OAZ-Smad1/4 complex binds to and activates the gene encoding Smad6, a specific inhibitor of the BMP pathway.

2000年1月21日 · We have identified the 30-zinc finger protein OAZ as a DNA-binding factor that associates with Smads in response to BMP2, forming a complex that transcriptionally activates the homeobox regulator of Xenopus mesoderm and neural development, Xvent-2.

2012年8月1日 · 这个符号叫失意体前屈失意体前屈，原本指的是网路上流行的表情符号：_|￣| 看起来像是一个人跪倒在地上，低着头，一副「天啊，你为何这样对我」的动作，虽然简单却很传神在初期的时候，并.