Osteopontin (OPN) is known as an active player in the progression of vascular remodeling diseases, however, the precise role in the proliferation of vascular smooth muscle cells (VSMC) is unclear. Thus, this study investigated the role of OPN in VSMC proliferation induced by 4-hydroxynonenal (HNE), …

前期研究表明,VSMCs表型转变受多种因素调控,如细胞因子、信号通路、细胞外基质、生物力等,靶向调控这些分子及信号通路可有效改善心血管疾病的进程。 因此,本文将对VSMCs表型转变的机制及其在心血管疾病中的作用进行阐述,以期为多种相关心血管疾病的临床治疗提供理论依据。 WEN Ting1,2, WANG Ruo-nan1,2, ZHANG Xiao-yan1, SUN Jia-xing3, ZHANG Xin-xin4, HAN Hua1,YAN Xian-chun1 (1. Department of Biochemistry and Molecular Biology, School of Basic …

2022年11月21日 · Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier experiments have found that VSMCs possess high plasticity. Vascular injury stimulates VSMCs to switch into a dedifferentiated type, also known as synthetic VSMCs, with a high migration and proliferation capacity for repairing vascular injury.

2023年9月1日 · OPN may be a key gene involved in VSMC proliferation in the AVF outflow veins and a therapeutic target to improve the AVF patency rate.

2000年11月1日 · Osteopontin (OPN) is an extracellular matrix protein that has been implicated in vascular smooth muscle cell (VSMC) adhesion. We have previously described the generation of OPN-deficient VSMC...

目的:探讨平滑肌22α(sm22α),平滑肌肌动蛋白(α-sma),骨桥蛋白(opn)在人胸主动脉 夹层中的表达及血管平滑肌细胞(vsmc)表型的变化.方法:收集人胸主动脉夹层(tad)动脉壁组织和正常人胸主动脉壁组织标本,采用免疫组化方法观察 sm22α,α-sma,opn的表达.结果:与正常主动脉组 ...

Results of this study suggest a pivotal role for AP-1-induced OPN expression in VSMC migration induced by HMGB1. Thus, the AP-1-OPN signaling axis in VSMC might serve as a potential therapeutic target for vascular remodeling in the injured vasculatures.

We have investigated the role of OPN in vSMC differentiation. Primary cultures of aortic mouse vSMCs were transfected with an OPN expression plasmid and several vSMC differentiation markers including α-SM actin (α-smooth muscle actin), SM22-α, tropomyosin and calponin were monitored in this cellular model. α-SM actin and calponin protein ...

2023年11月9日 · 黄辉教授团队早期发现血管平滑肌细胞(Vascular Smooth Muscle Cell, VSMC)发生成骨表型转化是血管钙化的主要发生机制(Circulation. 2022; J Clin Invest. 2021)，近年来研究也提示，机体衰老与血管钙化的发生密切相关。 GATA6是高度保守的GATA锌指转录因子家族成员，在生命早期对心血管系统的正常发育具有不可或缺的作用。 既往研究不仅证明GATA6具有促进VSMC分化和静止状态的作用，也表明其与炎性相关的合成表型有关，而补体参与的炎性衰老 …

2019年2月7日 · OPN (osteopontin) is a strong predictor of outcomes in patients with calcific aortic valve disease and ischemic vascular pathologies including stroke, myocardial infarction, and peripheral artery disease.