Recombinant Human N-Glycosylase/OGG1 是一种DNA修复酶，其作为一种修饰酶, 主要具有DNA糖基化酶活性和脱嘌呤/脱嘧啶（apurinic/apyrimidinic，AP）裂解酶活性两种活性。 N-糖 …

OGG1 is the primary enzyme responsible for the excision of 8-oxoguanine (8-oxoG), a mutagenic base byproduct that occurs as a result of exposure to reactive oxygen species (ROS). OGG1 …

2025年1月1日 · ROS oxidize Gua in the guanine-enriched region to form 8-oxoGua, and OGG1 recognizes and excises 8-oxoGua. The generation of the AP site in the promoter region leads …

2018年5月24日 · Results showed that OGG1-BER further increases the levels of ROS-induced DNA damage by generating repair intermediates, leading to PARP1 overactivation and cell death.

2024年6月1日 · ROS-inducing agents in combination with MTH1 inhibitors promote tumor cell parthanatos via OGG1-BER. A small amount of 8-oxoG integrated in the genome caused by …

2023年11月1日 · In this study, we deciphered the underlying molecular mechanism how ROS-responsive RelA/p65 Ser276 phosphorylation is affected by OGG1. ROS attacks genomic …

Our data reveal that a subset of Ogg1 −/− cells shows higher ROS levels (H ROS cells), while ~85% of Ogg1 −/− cells exhibit physiological levels of ROS (L ROS cells). Ogg1 −/− cells were …

2019年2月1日 · Cytokine-induced ROS temporarily transform OGG1 into an epigenetic regulator of inflammatory gene expression with substantial impact on the cytokines that control lung …

2023年9月29日 · Blockade of OGG1 binding to DNA also prevented promoter recruitment of RelA/p65, Pol II, and p-RNAP II in a gene-specific manner. Collectively, the data presented …

Oxidatively-induced DNA damage and its repair as a transcriptional modulator. Reactive oxygen species (ROS)-induced DNA damage. The examples described above establish two key …