Dec 25, 2024 · OGG1 (8-Oxoguanine DNA Glycosylase) is a Protein Coding gene. Diseases associated with OGG1 include Renal Cell Carcinoma, Nonpapillary and Clear Cell Renal Cell Carcinoma. Among its related pathways are Packaging Of Telomere Ends …

OGG1 excises 8-oxo-7,8-dihydroguanine (8-oxo-dG) lesion on DNA that is often induced by generation of reactive oxygen species (ROS) and has been linked to mutations, cancer development, and tissue damage.

A key enzyme in all these processes is 8-oxoguanine DNA glycosylase (OGG1), which, via non-catalytic binding to oxidatively-induced DNA damage in promoter regions, serves as a nucleation site around which changes in large-scale regulation of inflammation-associated gene …

OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage. Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locations. OGG1 prevents atherosclerosis-induced vascular endothelial cell injury through mediating DNA damage repair.

May 1, 2000 · In human cells, the OGG1 gene is localized on chromosome 3p25 and encodes two forms of hOgg1 protein which result from an alternative splicing of a single messenger RNA. The alpha-hOgg1 protein has a nuclear localization …

May 24, 2018 · Our study showed that OGG1 expression increased, while genetic or siRNA-mediated ablation of Ogg1, as well as expression of enzymatically deficient OGG1 decreased accumulation of DNA strand...

OGG1 binds the free 8-oxoG base with a high affinity, forming an OGG1•8-oxoG complex. Remarkably, this complex interacts with the RAS family GTPases, and catalyzes replacement of GDP with GTP. OGG1•8-oxoG, thus functions as a guanine nucleotide exchange factor (GEF) (Boldogh et al., 2012).

Sep 28, 2024 · The human glycosylase OGG1 extrudes and excises the oxidized DNA base 8-oxoguanine (8-oxoG) to initiate base excision repair and plays important roles in many pathological conditions such as ...

Feb 8, 2025 · Title: Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locations. OGG1 prevents atherosclerosis-induced vascular endothelial cell injury through mediating DNA damage repair.

8-Oxoguanine glycosylase (OGG1) is a base excision repair enzyme responsible for the recognition and removal of 8-oxoguanine, a commonly occurring oxidized DNA modification. OGG1 prevents the accumulation of mutations and regulates the transcription of various oxidative stress–response genes.