2015年3月6日 · One of the key antiviral factors induced by IFNs, 2′-5′ oligoadenylate synthase (OAS), is a well-known molecule that regulates the early phase of viral infection by degrading...

Summary: The 2',5'-oligoadenylate synthetase (OAS)-RNase L pathway is a classical antiviral innate immune pathway. Upon sensing dsRNA, OAS produces 2',5'-oligoadenylate (2-5A) as a …

2014年7月18日 · The oligoadenylate synthase (OAS) proteins and cyclic GMP–AMP synthase (cGAS) are enzymes that detect this danger and promote antiviral immunity.

2025年2月25日 · Activated RNase L cleaves both viral and host RNA and produces cleaved RNA fragments that activate RIG-I-like receptors, leading to type I interferon (IFN-I) signaling and …

2019年1月15日 · Interferon-inducible human oligoadenylate synthetase-like (OASL) and its mouse ortholog, Oasl2, enhance RNA-sensor RIG-I-mediated type I interferon (IFN) induction …

三种形式oas均能被ifn诱导，并随ifn的种类、细胞的种类、细胞的增长状况的不同而不同。 OAS广泛存在于人体细胞中，与干扰素调节因子(Interferon regu—latory factors IRF)结合的部分存在 …

2021年7月31日 · 该研究结果发表在国际期刊 《Science Immunology》 ，题目为 OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis。 RIG-I配体通过RIG-I非依赖性的、IFN …

2017年5月19日 · OASL was identified to be strongly induced following viral infection through engaging the RNA sensor RIG-I and increasing signaling through this pathway to enhance the …

OASL was identified to be strongly induced following viral infection through engaging the RNA sensor RIG-I and increasing signaling through this pathway to enhance the anti-viral type I IFN …

Type I interferon–inducible oligoadenylate synthetase 1 (OAS1) can initiate antiviral immune responses and is linked to pulmonary alveolar proteinosis with hypogammaglobulinemia. Here, …