O-glycosylation and its role in therapeutic proteins - PMC
In stark contrast with N-glycosylation, the bulk of O-glycosylation occurs in the Golgi after the protein has been folded. Unlike N-glycans, O-glycans are added to proteins one monosaccharide at a time by a myriad of different glycosyltransferases.
Glycosylation: mechanisms, biological functions and clinical
2024年8月5日 · Since the 2010s, the close connection between O-glycosylation and physiological processes such as inflammatory response, immune escape, viral infection, cell adhesion, metastasis, apoptosis,...
Chemical O‐Glycosylations: An Overview - Das - 2016
2016年8月17日 · Significant development in the area of chemical O-glycosylation strategies is evident from the literature. These novel approaches offer a solid platform to deal with various complex oligosaccharides relevant for biological applications.
Glycosylation in health and disease - Nature Reviews Nephrology
2019年3月11日 · Perhaps the most diverse form of protein glycosylation is O-glycosylation, in which glycans attach to the oxygen atom of the hydroxyl groups of Ser (S) or Thr (T) residues.
The role of O-glycosylation in human disease - PubMed
This review provides insights on the molecular mechanism underlying O-glycan biosynthesis and modification, and highlights illustrative examples of diseases that are triggered or modulated by aberrant cellular O-glycosylation.
O-glycosylation O-glycosylation is generally an oxygen linkage of glycans to the Ser or Thr residues, followed by a gradual addition of mono-saccharides.
Functional Roles of O -Glycosylation - PubMed Central (PMC)
O -Glycosylation in general has impact on a diversity of biological processes covering cellular aspects (targeted transport of glycoproteins), molecular aspects (protein conformation, resistance to proteolysis), and aspects involved in cellular communication (cell …
Global functions of O-glycosylation: promises and challenges in O ...
High-throughput O-glycoproteomics have enabled us to draw a comprehensive map of O-glycosylation, and mining this information has supported the definition and confirmation of functions related to site-specific O-glycans.
Concepts and principles of O-linked glycosylation - PubMed
We also describe some of the physical and biological properties that O-glycosylation confers on the protein to which the sugars are attached. These include providing the basis for rigid conformations and for protein stability.
O-Linked Glycosylation - an overview | ScienceDirect Topics
Here we provide an overview on the best characterized flagellin O-glycosylation and general O-glycosylation pathways and describe some of the specialized systems present in Gram-negative and Gram-positive bacteria.
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