Dihydroorotate dehydrogenase (DHODH) is an enzyme that in humans is encoded by the DHODH gene on chromosome 16. The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone -mediated oxidation of dihydroorotate to orotate, in de …

2020年6月1日 · Dihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis pathway that provides nucleotides for RNA/DNA synthesis essential for proliferation. In mammalian cells, DHODH is localized in mitochondria, linked to the respiratory chain via the coenzyme Q pool.

2019年4月2日 · In this report we describe the discovery and characterization of BAY 2402234 - a novel, potent, selective and orally bioavailable DHODH inhibitor that shows monotherapy efficacy and differentiation...

2025年3月28日 · DHDH (Dihydrodiol Dehydrogenase) is a Protein Coding gene. Diseases associated with DHDH include Developmental Dysplasia Of The Hip 1 and Developmental Dysplasia Of The Hip 2. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity.

2017年1月13日 · We developed an assay method for measuring dihydroorotate dehydrogenase (DHODH) activity in cultured HeLa cells and fibroblasts, and in stage III stomach cancer and adjacent normal tissues from the...

Dihydroorotate dehydrogenase (DHODH) is a ubiquitous enzyme located within the inner membrane of the mitochondria. Using the cofactor ubiquinone, DHODH catalyzes the fourth step of de novo pyrimidine synthesis: the conversion of dihydroorotate to orotate.

2021年5月10日 · Dihydroorotate dehydrogenase (DHODH), located in the inner membrane of mitochondria, is an iron-containing flavin-dependent enzyme and plays a crucial role in the de novo synthesis of pyrimidine [4].

2019年3月1日 · One enzyme essential for the de novo biosynthesis of pyrimidine-based nucleotides is dihydroorotate dehydrogenase (DHODH), a known therapeutic target for multiple diseases.

2010年6月3日 · Dihydroorotate dehydrogenase (DHODH) is an enzyme located in the inner mitochondrial membrane that serves as a mitochondrial regulator. It has the ability to autonomously regulate ferroptosis, separate from the action of GPX4. DHODH functions as a rate-limiting enzyme in the fourth step of the de novo production of pyrimidine nucleotides [69].

2025年3月14日 · Findings: Mechanistically, DHDH mediated the synthesis and depletion of the substrate D-xylose and inhibited the activation of the proteasome subunit beta type 9 (PSMB9) and further induction of the immune response.