2024年12月17日 · Here, we report the crystal structure of NYN domain of human KHNYN with a 7mer single strand RNA from the AU-rich element of IFNL3 (interferon lambda 3). We describe the detailed RNA-protein interactions and the formation of a head-to-tail dimer of KHNYN and other NYN domain proteins.

2015年12月29日 · The NYN metallonuclease domain has been identified in two other endonucleases, the organellar PRORP1 from Arabidopsis (Howard et al., 2012, 2015; Gobert et al., 2013) and in MCPIP1 from mammals.

而在曲奇创作中，NYN凭借独特的角色定位和泛用的语录获得了一席之地，人气稳步上升，最终在2016年伴随着 HSI姐贵 热潮迎来了长久的 创作热潮 D S S Q。 现如今，NYN的人气已经比肩甚至超越了 UDK姐贵 和 KNN姐贵 等老牌角色，以至于在一些非相关领域也能见到对其的大肆讨论。 2016年6月27日， RK姐贵 在一次生放送中不小心露脸。 随后NYN姐贵发送了一条推特，被认为是在嘲讽RK姐贵的相貌。 次日，NYN姐贵陆续关闭了自己的推特、P站、 koe部 账号，且并未 …

2014年6月3日 · Melrose PLC (NYN) 2013年年度报告「LSE」.pdf，点击即可下载。 包含的报告内容，文档格式为PDF，大小6.09MB，页数156页，字数约560016字，欢迎会员下载 三个皮匠报告—— 严选型全行业研究报告分享下载平台，您的专属行业智库！

Here, we solve the crystal structure of the Rae1 (YacP) protein of Bacillus subtilis, a founding member of the NYN (Nedd4‐BP1/YacP nuclease) subfamily of PIN domain proteins, and identify potential substrates in vivo. Unexpectedly, degradation of a characterised target mRNA was completely dependent on both its translation and reading frame.

In this study, we recombine the PAM-interacting domain of SpRY, a broad-targeting Cas9 possessing an NRN > NYN (R = A or G, Y = C or T) PAM preference, with the N-terminus of Sc + +, a Cas9 with simultaneously broad, efficient, and accurate NNG editing capabilities, to generate a chimeric enzyme with highly flexible PAM preference: SpRYc.

nyn 结构域基因家族由编码核糖核酸酶的基因组成，这些核糖核酸酶的特征是新发现的 nyn 结构域。 该家族的成员广泛分布在所有生命界中，并在各种 RNA 调控过程中发挥着至关重要的作用，尽管 NYN 结构域基因家族的广泛基因组概述尚未在任何物种中可用。

2013年5月1日 · MIA AT NYN - June 08, 2013

These domains are found in the eukaryotic proteins typified by the Nedd4-binding protein 1 and the bacterial YacP-like proteins (Nedd4-BP1, YacP nucleases; NYN domains). We show that the NYN domain shares a common protein fold with two other previously characterized groups of nucleases, namely the PIN (PilT N-terminal) and FLAP/5' --> 3 ...

2024年4月8日 · Structural modelling and in vitro ribonuclease assays reveal that NYN displays. robust sequence-nonspecific, Mn2+-dependent ssRNA-cleavage activity. Our findings suggest a role. CRISPR antiviral defence. This study sheds light …