Nrf2 suppresses macrophage inflammatory response by blocking ...
2016年5月23日 · Here, we demonstrate that Nrf2 interferes with lipopolysaccharide-induced transcriptional upregulation of proinflammatory cytokines, including IL-6 and IL-1β. Chromatin immunoprecipitation...
Nrf2 suppresses macrophage inflammatory response by …
2016年5月23日 · Here, we demonstrate that Nrf2 interferes with lipopolysaccharide-induced transcriptional upregulation of proinflammatory cytokines, including IL-6 and IL-1β. Chromatin immunoprecipitation (ChIP)-seq and ChIP-qPCR analyses revealed that Nrf2 binds to the proximity of these genes in macrophages and inhibits RNA Pol II recruitment.
Nrf2 activation reprograms macrophage intermediary …
2022年2月18日 · To understand how Nrf2 regulates macrophage biology, we used high-resolution mass spectrometry (MS) to characterize the proteomes of bone marrow-derived macrophages (BMDMs) differentiated ex vivo from bone marrow cells isolated from, respectively, wild-type (WT), Keap1-knockdown (Keap1-KD, expressing ∼70% lower levels of Keap1 compared to WT ...
Macrophage achieves self-protection against oxidative stress …
2019年2月14日 · We further show that Mst1/2 function as critical ROS sensors and attenuators through stabilizing nuclear factor (erythroid-derived 2)-like 2 (Nrf2, also known as NFE2L2), a major antioxidant...
Nrf2 signaling pathway: Pivotal roles in inflammation
2017年2月1日 · A very recent investigation based on chromatin immunoprecipitation (ChIP)-seq and ChIP-qPCR results in mouse macrophages revealed that Nrf2 binds to the promoter regions of pro-inflammatory cytokines such as IL-6 and IL-1β and inhibits RNA Pol II recruitment.
Nrf2 Signaling in Macrophages - PMC - National Center for …
Macrophages act as major players in inflammatory responses. Because oxidative stress and inflammation are two intertwined processes, the anti-inflammatory activity of Nrf2 signaling is believed to result from its upregulation of cellular antioxidant defenses via the antioxidant response element-driven transcription.
Itaconate is an anti-inflammatory metabolite that activates Nrf2 …
2018年3月28日 · Our findings demonstrate that itaconate is a crucial anti-inflammatory metabolite that acts via Nrf2 to limit inflammation and modulate type I interferons. Macrophages have a key role in innate...
Nrf2-mediated anti-inflammatory polarization of macrophages as ...
2022年8月12日 · In this review, we reviewed the role of macrophage phenotypes in driving and relieving inflammation due to OA and summarized how NF-κB, Nrf2, and their crosstalk shape macrophage polarization. As Nrf2 signaling is believed to impact cellular metabolism, studying the effects of activators of Nrf2 on macrophage metabolism and phenotype related ...
Macrophage nuclear factor erythroid 2-related factor 2 ... - PubMed
Background and aims: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of reactive oxygen species (ROS) and inflammation and has been implicated in both human and murine inflammatory disease models. We aimed to characterize the roles of macrophage-specific Nrf2 in liver ischemia/reperfusion injury (IRI).
Nrf2 activation drive macrophages polarization and cancer cell ...
2018年9月4日 · The Nrf2 activation of macrophages correlated with the reactive oxygen species induced by cancer cells derived lactate. Cancer cells educated macrophages could activate Nrf2 of the cancer cells, in turn, to increase cancer cells epithelial-mesenchymal transition (EMT) through paracrine VEGF.