十分钟带你认识Keap1-Nrf2-ARE信号通路 - 知乎 - 知乎专栏
当Nrf2转位到细胞核内，以Nrf2-Maf 的形式与ARE 结合，通过相关激活程序，使下游基因转录，常见的下游基因产物包括 醌氧化还原酶 (NAD(P)H:quinone oxidoreductase 1, NQO1)、谷胱甘肽 硫基转移酶 (glutathione-S-transferses, GSTs)、 谷氨酰半胱氨酸连接酶 …
An Overview of the Nrf2/ARE Pathway and Its Role in …
In this study, we review evidence for the Nrf2/ARE-driven pathway dysfunctions leading to various neurological pathologies, such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, as well as amyotrophic lateral sclerosis, and the beneficial role of natural and synthetic molecules that are able to interact with Nrf2 to enhance its protective...
Nrf2-ARE pathway: An emerging target against oxidative stress …
We will address the role of the nuclear factor E2-related factor 2 (Nrf2) as a potential target for the treatment of NDDs. The Nrf2-ARE pathway is an intrinsic mechanism of defence against oxidative stress.
The Nrf2-ARE Pathway: An Indicator and Modulator of Oxidative …
Transcriptional activation of protective genes is mediated by a cis-acting element called the antioxidant responsive element (ARE). The transcription factor Nrf2 (NF-E2-related factor 2) binds to the ARE. Activation of this pathway protects cells from oxidative stress-induced cell death.
机理洞察 | 氧化应激信号通路：NRF2核因子 - 知乎
核因子（NRF2） 是一种转录因子，它通过表达参与氧化应激响应和药物解毒的基因有效调节细胞对 有毒物质和氧化损伤的防御能力。 NRF2的活动受到复杂的转录和翻译后网络的严格调控，使其能够协调细胞对各种病理性应激因素的响应和适应，从而维持细胞稳态。 一项研究表明，NRF2处于一个复杂调控网络的中心，这确立了NRF2作为一个真正的多效性转录因子的地位。 作为CNC转录因子家族的一员，NRF2由七个Neh域 (Nrf2 ECH 同源结构域) 组成，每个域具有不同的功 …
氧化和化学应激的防御性转导通路——Nrf2/ARE
Nrf2/ARE是近年新发现的机体抵抗内外界氧化和化学等刺激的防御性转导通路．生理条件下，NF-E2相关因子2 (Nrf2，NF-E2-related factor 2)在细胞质中与Keap1结合处于非活性、易降解的状态.在内外界自由基和化学物质刺激时，Keap1的构象改变或者Nrf2直接被磷酸化，导致Nrf2与Keap1解离而活化．活化的Nrf2进入细胞核，与抗氧化反应元件...
Nuclear factor erythroid 2-related factor 2 (Nrf2)
Nuclear factor-erythroid 2 related factor 2 (Nrf2) is a ubiquitous master transcription factor. Nrf2 upregulates antioxidant response elements (AREs)-mediated expression of antioxidant enzyme and cytoprotective proteins.
An Overview of the Nrf2/ARE Pathway and Its Role in ... - MDPI
2021年9月4日 · In this study, we review evidence for the Nrf2/ARE-driven pathway dysfunctions leading to various neurological pathologies, such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, as well as amyotrophic lateral sclerosis, and the beneficial role of natural and synthetic molecules that are able to interact with Nrf2 to enhance its ...
氧化和化学应激的防御性转导通路——Nrf2/ARE - pku.edu.cn
Nrf2/ARE是近年新发现的机体抵抗内外界氧化和化学等刺激的防御性转导通路.生理条件下,NF-E2相关因子2 (Nrf2,NF-E2-related factor 2)在细胞质中与Keapl结合处于非活性、易降解的状态.在内外界自由基和化学物质刺激时,Keapl的构象改变或者Nrf2直接被磷酸化,导致Nrf2与Keap1解离而活化.活化的Nrf2进入细胞核,与抗氧化反应元件...
Nrf2-ARE信号通路功能与临床疾病及相关药物的研究新进展
Nrf2-ARE则是近年来新发现的细胞氧化应激反应的关键传导通路，当其在体内被有毒有害物质激活后转位进入细胞核能与抗氧化反应元件（antioxidant response element，ARE）结合形成Nrf2-ARE信号通路，从而调控下游抗氧化蛋白、氧化酶和Ⅱ相解毒酶等。