Detailed studies of the properties of 3H-3-N-methylspiperone (NMSP) binding in rat and human brain homogenates were performed at 37 degrees C. In homogenates of rat striatum and frontal cortex and human caudate and frontal cortex tissues, the …

引用本文: 早期帕金森病壳核多巴胺D2受体的上调:11C-RAC和11C-NMSP PET显像的对比研究 [J] . 国外医学（放射医学核医学分册）, 2001, 25 (01) : 20-21.

It has been observed that the D2 receptor can exist in both a monomer and dimer form and that a NMSP photolabel ligand binds primarily to the monomer form while a RAC-like photolabel ligand binds both.

This study confirms an increase in dopamine D2 receptors in the putamen contralateral to the predominant symptoms, compared with the ipsilateral putamen, in early Parkinson's disease. This increase was seen both with reversible ligand [11C]RAC and with irreversible ligand [11C]NMSP and thus does not …

Dopamine D2 receptor binding potential (BP) was measured by C-11 N-methylspiperone (NMSP) and PET in normal healthy volunteers and patients with various neurodegenerative diseases including Parkinson disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), corticobasal dege …

2005年11月3日 · Spiperone and its analog, 3- N -methylspiperone (NMSP), are high-affinity D 2/3 dopamine and 5-HT 2A serotonin receptor antagonists, showing a low affinity for α 1 -adrenergic receptors (8, 9). 3- N - [11 C]Methylspiperone ( [11 C]NMSP) has been studied as a positron emission tomography (PET) tracer for imaging D 2/3 and 5HT 2A receptor densities.

1986年10月1日 · The pharmacological properties of the specific binding in rat striatal and human caudate tissues were very similar and indicated the presence of brain D2 dopamine receptors.

Dopamine D 2 receptor binding characteristics were studied by positron emission tomography (PET) using N- 11 C-methyl spiperone as receptor ligand in patients on longterm treatment with neuroleptic drugs and in control subjects. Eight of the patients had symptoms of tardive dyskinesia whereas three patients did not have any symptoms.

Wong, D. F., S2 Serotonin Receptor Binding Of C-11-3-n-Methylspiperone (NMSP) in Patients with Depression Following Stroke., Journal of Nuclear Medicine 27: 1074 (1986).

1995年8月8日 · The dopamine hypothesis of schizophrenia received strong support when a two- to three-fold elevation of D2 receptor densities was demonstrated by positron emission tomography (PET) and [11C]N-methylspiperone ( [11C]NMSP). In the present study, the reproducibility of this finding was examined by appli …