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2025年1月1日 · We used genetic and pharmacological approaches to define the role of AMPK at the NMJ. Old mice displayed reduced AMPK activity and synapse-specific mitochondrial transcripts. Young AMPK mKO mice exhibited a neuromuscular phenotype similar to aged animals. Active AMPK localized in subsynaptic nuclei and preceded NMJ transcript expression.

人类行走、呼吸等行为，需要运动神经元的轴突进行超远距离投射（可超过1米），与肌纤维形成突触连接（Neuromuscular junction，NMJ），从而控制骨骼肌收缩和运动。 NMJ病变将引起一系列神经肌肉疾病，包括肌萎缩侧索硬化症/渐冻症和重症肌无力等。 NMJ突触局部需要大量的信息交换，蛋白质如果在胞体合成通过轴突长距离运输（0.002-4.5...

2023年12月19日 · Here, we report the development of a robust and efficient self-organizing neuromuscular junction (soNMJ) model from human pluripotent stem cells that can be maintained long-term in simple adherent...

2018年3月14日 · Part of the book series: Current Clinical Neurology ( (CCNEU)) The neuromuscular junction (NMJ) is a cholinergic synapse that connects a motor neuron to a skeletal muscle fiber. To enable sustained tetanic contraction of skeletal muscle, the NMJ must reliably transmit the impulses from the presynaptic motor neuron to the postsynaptic muscle fiber.

2020年9月9日 · Here, we demonstrate that long-term rapamycin treatment is overwhelmingly positive in aging skeletal muscle, preserving muscle size, function, and neuromuscular junction (NMJ) integrity....

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