最近的研究揭示了GluN2A和GluN2B-NMDARs不是随机分布在突触上，而是组织在不同且基本上不重叠的纳米结构域中，并且与CaMKIIa的相互作用是组织GluN2B-NMDAR的关键。 突触处的NMDARs信号传导可能来自GluN2A-和GluN2B-NMDAR复合物的纳米级镶嵌，其中（1）稳定的GluN2A-NMDAR纳米结构域充当离子性钙提供方以触发激酶活化，而（2）不稳定的Glu2B-NMDAR穿梭并为细胞内信号伴侣提供结构支架 [Fig.3B]。 3、NMDAR在神经和精神疾病中的 …

Glutamate [NMDA] receptor subunit epsilon-2, also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B), is a protein that in humans is encoded by the GRIN2B gene.

首先，课题组对过去的实验进行了重复，并成功通过药物阻断的方式在TBS (θ突发刺激)电流和甘氨酸灌流刺激下单独对海马切片中NMDAR和AMPAR介导的LTP进行记录。 随后，课题组 以刺激后65毫秒时的诱发电流值作为观测值，发现两种受体介导的LTP的观测值没有差异，即两种受体介导的LTP具有同步性。 SNARE（核孔复合体）依赖性AMPAR快速插入突触后表面引起AMPAR- LTP中AMPAR膜表面表达上调和 突触传递 增强。 那么依赖SNARE的NMDAR膜转运是否也 …

新的研究表明， N-甲基-D-天冬氨酸受体 （简称 NMDARs） 是哺乳动物中枢神经系统中生理和病理的基础；也是一类谷氨酸门控，钙渗透性神经递质受体 【1-2】。 NMDARs控制成人突触的可塑性，以及启动巩固神经系统适应性过程所必需的转录反应，比如记忆和获得性神经保护等【3-4】。 然而NMDARs对神经元也有有害的一面，它们可以启动转录关闭通路，导致线粒体功能障碍，甚至导致过量谷氨酸引起的兴奋性毒性细胞死亡 【5-6】。 尽管NMDA受体所诱导的兴奋性毒性被 …

To assess in detail the molecular mechanisms of autoantibody-induced NMDAR endocytosis, vesicular trafficking, and exocytosis we transiently co-expressed rat GluN1-1a-EGFP and GluN2B-ECFP alone or together with scaffolding postsynaptic density protein 95 (PSD-95), wild-type (WT), or dominant-negative (DN) mutant Ras-related in brain (RAB) protei...

Polyclonal Antibody for studying NMDAR2B. Validated for WB. Highly specific and rigorously validated in-house, NMDA Receptor 2B (GluN2B) Antibody (CST #4207) is ready to ship.

2023年1月28日 · In breast cancers, NMDAR2B shows different expression patterns among the various subtypes: high levels of NMDAR2B associate with the HER2 subtype, whereas negative expression correlates more with the luminal subtype [91].

Our findings demonstrate that CA exerts neuroprotective effects in an in vitro model of AD by regulating NMDAR2B and its downstream cascades, highlighting the therapeutic potential of CA as a NMDARs-targeted candidate in the treatment of AD.

2022年11月1日 · Gain-of-function and loss-of-function approaches provided insight into the differential roles of NR2A and NR2B in mediating peripheral and central nociceptive sensitization induced by IANX, which may be a fundamental basis for advancing knowledge of the neural mechanisms’ reaction to nerve injury. 1. Introduction.

2025年3月30日 · GRIN2B (Glutamate Ionotropic Receptor NMDA Type Subunit 2B) is a Protein Coding gene. Diseases associated with GRIN2B include Developmental And Epileptic Encephalopathy 27 and Intellectual Developmental Disorder, Autosomal Dominant 6, With Or Without Seizures.