2023年3月20日 · NLRP10 is highly expressed in differentiated human keratinocytes, in which it can also assemble an inflammasome. Our study shows that this inflammasome surveils mitochondrial integrity. These...

2024年12月25日 · NLRP10 (NLR Family Pyrin Domain Containing 10) is a Protein Coding gene. Diseases associated with NLRP10 include Cinca Syndrome. Among its related pathways is Nucleotide-binding oligomerization domain (NOD) pathway. An important paralog of …

2012年4月25日 · NLRP10 (also known as PYNOD, NALP10, PAN5 and NOD8) is the only NLR lacking the putative ligand-binding leucine-rich-repeat domain, and has been postulated to be a negative regulator of other NLR members, including NLRP3 (refs 4-6).

NLRP10, short for NOD-like receptor family pyrin domain containing 10, is an intracellular protein of mammals that functions in apoptosis and the immune system.

2023年3月22日 · So, here are ten things that we learn about NLRP10 from the two new studies: (1) NLRP10 senses a loss in cellular homeostasis triggered by 3m3-FBS; (2) it is recruited to mitochondria that have...

2024年10月18日 · Our findings underscore NLRP10 as a key player in atopic dermatitis pathogenesis, highlighting NLRP10 as a potential target for therapeutic intervention to restore skin barrier function and ...

NLRP10 (also known as PYNOD, NALP10, PAN5 and NOD8) is the only NLR lacking the putative ligand binding leucine rich repeat domain, and has been postulated to be a negative regulator of other NLR members including NLRP3 4 – 6.

2015年3月6日 · NLRP10是NOD样受体(NOD-like receptor，NLR)蛋白家族的特殊成员，它具有N端热蛋白结构域(pyrin-like domain，PYD)和中间的核苷酸结合寡聚结构域 (nucleotide-binding and oligomerization domain，NOD)，却不具有亮氨酸富集重复结构域(leucine-rich repeat domain，LRR)，这表明NLRP10可能并不直接 ...

Unlike other nucleotide oligomerization domain-like receptors, Nlrp10 lacks a canonical leucine-rich repeat domain, suggesting that it is incapable of signal sensing and inflammasome formation. Here we show that mouse Nlrp10 is expressed in distal …

2023年4月12日 · NLRP10 is the only NOD-like receptor protein lacking leucine-rich repeats, suggesting that NLRP10 may be a regulatory protein. The aim of this study was to investigate the regulatory role of NLRP10 on NLRP1 and NLRP3 inflammasome in human periodontal ligament cells (HPDLCs) under AGEs treatment.