可溶性HLA-G（sHLA-G）对NK细胞（CD56bright和CD56dim）的趋化性、细胞因子和趋化因子的分泌有不同程度的调节作用。 sHLA-G上调了CD56bright和CD56dimNK细胞CCL2的分泌，以及外周血CD56dim NK细胞CCL2、CCL8和CXCL2-CXCL3的分泌。

NK细胞作为造血干细胞移植后最先重建的固有免疫细胞，有开发成为通用型细胞产品的潜力。 本文从基础HLA和KIR生物学知识开始，回顾分析国外多年积累的临床数据，以期对这一话题进行一个详细的总结。 目录 一、HLA的生物学原理 二、KIR的生物学原理

Natural killer (NK) cells are innate lymphocytes that can kill diseased- or virally-infected cells, mediate antibody dependent cytotoxicity and produce type I immune-associated cytokines upon activation. NK cells also contribute to the allo-immune ...

4 天之前 · To investigate potential NK escape mechanisms, we examined the expression of CD30, HLA class I, HLA-E and MICA in available paired tumor samples before treatment and at relapse.

2020年2月17日 · The cytolytic function of NK cells is tightly controlled by activating and inhibitory receptors expressed on the cell surface. Ligands that interact with a variety of NK-cell receptors include the human leukocyte antigen (HLA) molecules, and the regulation of NK-cell function by HLA class I molecules is well-established.

2019年2月18日 · Human NK cells express two different classes of HLA-class I-specific inhibitory receptors: members of the KIR/CD158 family and the CD94/NKG2A (CD94/CD159a) heterodimer. 5, 45 KIRs are type I ...

NK cells are cytotoxic lymphocytes of the innate immune system with a variety of roles, including defense against virus-infected or malignant cells that lack surface expression of Human Leukocyte Antigen (HLA) class I antigen presenting molecules (5).

2024年12月1日 · We hypothesize that a critical discriminating factor in KIR–HLA-I interactions is the selective detection of HLA-I-bound peptides by KIRs. We propose a ‘peptide selectivity model’, where high-avidity KIR–HLA-I interactions reflect low selectivity for peptides conferring consistent NK cell inhibition across different tissue immunopeptidomes.

Regulating human NK cells are two distinctive HLA class I receptors: variable KIR that recognize polymorphic HLA-A, -B and –C and invariant CD94:NKG2A that recognizes the complex of HLA-E and a peptide cleaved from an HLA-A, -B and –C leader sequence.

19 小时之前 · In contrast, neither NK nor CAR-NK cells showed significant lysis of Raji cells, which do not express CD5 but have high levels of HLA-I and HLA-II expression (Fig. 2 c).