JEM丨浙大靳津组揭示自身免疫病新型调控分子机制 - 知乎
CRL4作为泛素连接酶，可以通过结合不同的接头蛋白（称为DCAFs，DDB1-cullin 4–associated factors），这些接头蛋白可以招募底物到泛素连接酶上发挥多种生理学功能。DCAF2（又称 …
NIK-associated isease now ranges from immunodeficiency (when NIK is defective) to autoimmunity, cancer, sterile inflammation, fibrosis, and meta-bolic ... Ddb1-Pathological …
Damage-specific DNA binding protein 1 (DDB1): a protein with a …
CUL4-DDB1 E3-ligase complex regulates the selective proteolysis of key proteins in DNA repair, replication and transcription. In addition, DDB1 plays a role in transcriptional regulation of UV …
Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked …
2023年11月22日 · V10R, L13R and W14R point mutants were chosen because they are located within the N-terminal helix-loop-helix motif and mediate interactions between WD40-N and …
DCAFs, the Missing Link of the CUL4-DDB1 Ubiquitin Ligase
2007年6月22日 · The CUL4-DDB1 ubiquitin ligase regulates cell proliferation, survival, DNA repair, and genomic integrity through targeted ubiquitination of key regulators, yet the …
Damage-specific DNA binding protein 1 (DDB1): a protein with a …
2011年12月1日 · The human DDB1 gene is located on chromosome 11q12-q13 and codes for a protein comprising 1140 amino acids with a molecular mass of 127 KDa (Tang and Chu, …
NIK as a Druggable Mediator of Tissue Injury - Cell Press
2019年3月26日 · NF-κB-inducing kinase (NIK, MAP3K14) is best known as the apical kinase that triggers non-canonical NF-κB activation and by its role in the immune system. Recent data …
损伤特异性 DNA 结合蛋白 1（DDB1）基因 | MCE
损伤特异性 DNA 结合蛋白 1： 由该基因编码的蛋白质是异二聚体 DNA 损伤结合 (DDB) 复合物的大亚基 (p127) ，而另一种蛋白质 (p48) 形成小亚基。这种蛋白质复合物在核苷酸切除修复中 …
汪洌教授课题组在cellular & molecular immunology线上发表研究论文阐述了DDB1 …
2020年3月5日 · DDB1在B细胞前体pro-B和pre-B中有较高表达，造血系统缺失DDB1会导致骨髓功能衰竭，B细胞分化也受到抑制，但DDB1在B细胞发育过程中的作用机制还不明确。汪洌教授 …
Interaction of DDB1 with NBS1 in a DNA Damage Checkpoint …
2024年12月5日 · Various DNA damage checkpoint control mechanisms in eukaryotic cells help maintain genomic integrity. Among these, NBS1, a key component of the MRE11-RAD50 …