In ischaemic cardiomyopathy, ventricular dysfunction is a consequence of myocardial ischaemia and infarction related to coronary arteriosclerosis, while there are many potential causes of non‐ischaemic cardiomyopathy (NICM), including haemodynamic pathology, infection, immunologic abnormalities, toxic injury, or genetic factors.

Data sources for accurate classification reference of NICM, including clinical characteristics, pathology, imaging manifestations, genomics and proteomics, etiology, and multimodal deep learning of patients. We have summarized the current accurate classification criteria and characteristics of each subtype of cardiomyopathy (Fig. 2). Currently ...

We review characteristic CMR features in ischemic and non-ischemic cardiomyopathies (ICM and NICM), especially in terms of the location and distribution of late gadolinium enhancement (LGE). CMR in ICM shows segmental wall motion abnormalities or wall thinning in a particular coronary arterial territory, and the subendocardial or transmural LGE.

Estimates of the prevalence of NICM range from 2–15% in community or hospital settings, and up to 50% in large clinical trials.1 Although the causes of NICM are many and varied, they generally culminate in a final common pathway of myocardial injury leading to ventricular dysfunction and clinical heart failure.

NICM is a heterogeneous condition with a variety of causes, including inflammation, genetic abnormalities, toxin exposure, and chronic tachycardia/ectopy. The reversibility of systolic dysfunction and overall prognosis is related to etiology, and the risk of life-threatening ventricular arrhythmias is higher in some conditions (e.g ...

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2016年12月19日 · We identified 6 RCTs enrolling 2970 patients with NICM to study the efficacy of ICDs for primary prevention. Pooled analysis of the 6 RCTs (including those with CRT defibrillator) demonstrated a statistically significant 23% risk reduction in all-cause mortality in favor of ICD therapy (hazard ratio, 0.77; 95% CI, 0.64–0.91) ( Figure ).

Background: Delayed contrast enhancement in cardiac magnetic resonance (CMR) imaging plays a pivotal role in assessing myocardial tissue characteristics in non-ischemic cardiomyopathy (NICM). This study aims to explore the various patterns of late gadolinium enhancement (LGE) observed in NICM patients and their correlation with clinical outcomes.

一项丹麦的研究通过评估了ICD对非缺血性心脏收缩期心力衰竭患者死亡率（DANISH）疗效的数据表明，植入式心律转复除颤器（ICD）减少了心源性猝死，但是其并没有降低非缺血性心肌病（NICM）患者的总死亡率。 近期，一项发表在杂志HEART上的研究进行了荟萃分析，以评估ICD治疗对NICM患者死亡率的影响。 此项研究系统地搜索了ICD对NICM患者结局的影响。 此项分析将随机分配到ICD的患者与随机分为无. 一项丹麦的研究通过评估了ICD对非缺血性心脏收缩 …

2008年9月11日 · Nonischemic cardiomyopathy (NICM) represents a heterogeneous group of conditions that can cause left ventricular dysfunction. 1 Studies have suggested that patients with NICM who have received implantable cardioverter-defibrillator (ICD) therapy in addition to standard medical therapy have better survival. 2,3 There are few data on whether the ...