2023年11月2日 · In vitro knockout (KO) of NFAT1 (NFATc2) or NFAT2 (NFATc1) enhanced NK cell degranulation and resulted in increased production of granzyme B and perforin upon …

2016年12月2日 · When we employed NK cells with knockout (KO) of NFAT 1, 2, and 4 in comparative in vitro analyses, we surprisingly found that lack of NFAT resulted in enhanced …

2023年9月14日 · Here we found that NFAT5, an NFAT family transcription factor that lacks an AP-1 docking site, was highly expressed in exhausted CD8 + T cells in the context of chronic …

2016年12月2日 · 通过在同基因 b16 黑色素瘤模型中使用 wt 和种系 nfat ko 动物，在体内进一步证实了 nfat 对 nk 细胞效应器功能的抑制作用，这表明 nfat ko 小鼠的转移负担显着降低。

2024年2月12日 · To understand how NFAT signaling regulates CD8 + T cell differentiation, we performed detailed transcriptional profiling of NFATc1 KO, NFATc2 KO, NFAT DKO and WT …

2023年10月30日 · We found that activated T cells significantly upregulated γc expression, wherein NFAT1 and NFκB were key in transcriptional upregulation via T cell receptor …

2023年9月1日 · NFAT regulates various functions in breast cancer cells, including invasion, tumor growth, and angiogenesis. The Cn/NFAT pathway was shown to be activated in a cohort of …

活化的T细胞核内因子（Nuclear Factors of activated T cells，NFAT）是一类转录因子家族，最初是在活化的T细胞中作为一种能够结合在人白介素-2（Interleukin-2，IL-2）的启动子上的快速 …

2016年12月2日 · When we employed NK cells with knockout (KO) of NFAT 1, 2, and 4 in comparative in vitro analyses, we surprisingly found that lack of NFAT resulted in enhanced …

6 天之前 · Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, et al. Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation. Cell Mol Immunol. 2023;20:1127–39.