STIM1-mediated NFAT signaling synergizes with STAT1 to control …
2025年2月21日 · We demonstrate that SOCE promotes nuclear factor of activated T cells (NFAT) binding to conserved noncoding sequence (CNS)-12 in the TBX21 enhancer and enables …
Hepatic NFAT signaling regulates the expression of inflammatory ...
Gene reporter assays and ChIP-PCR demonstrated that NFAT response element in its promoter played a key role in BA-induced human IL-8 expression. Finally, blocking NFAT activation in …
NFAT isoforms control activity-dependent muscle fiber type ...
2009年8月11日 · To localize all NFATs in adult muscle, we analyzed soleus and EDL by immunohistochemistry (IHC) with NFAT isoform-specific antibodies. The staining specificity …
NFATC1 antibody (66963-1-Ig) | Proteintech - ptglab
66963-1-Ig targets NFATC1 in WB, IHC, IF, IP, ELISA applications and shows reactivity with human samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. …
一文搞定|活化的T细胞核内因子 (NFAT)的结构及其功能
2024年6月27日 · 活化的T细胞核内因子（Nuclear Factors of activated T cells， NFAT）是一类转录因子家族，最初是在活化的 T 细胞中作为一种能够结合在人白介素 - 2（Interleukin-2， IL …
NFAT
NFAT是具有多向调节功能的转录因子，如调节T细胞的活化，分化及自身耐受性等。 NFAT在多种免疫细胞均有表达，在机体免疫应答中诱导细胞因子及其他基因的转录。
NFATc2 and NFATc3 regulate T - Nature
2001年12月10日 · These results demonstrate a key role for NFATc2 and NFATc3 in modulating T cell receptor responsiveness and regulating subsequent cell division and T H 2 differentiation. …
NFAT, immunity and cancer: a transcription factor comes of age
2010年8月20日 · This Review focuses on recent advances in our understanding of the transcriptional functions of NFAT proteins in the immune system and provides new insights …
NFAT control of immune function: New Frontiers for an Abiding …
2018年3月2日 · Nuclear factor of activated T cells (NFAT) was first described almost three decades ago as a Ca <sup>2+</sup>/calcineurin-regulated transcription factor in T cells. …
Hepatic NFAT signaling regulates the expression of ... - bioRxiv
2020年3月26日 · Gene reporter assays and ChIP-PCR demonstrated that the NFAT response element in its promoter played a key role in BA-induced human IL-8 expression. Together our …