2001年4月30日 · Concomitant induction of NFAT and AP-1 requires concerted activation of two different signaling pathways: calcium/calcineurin, which promotes NFAT dephosphorylation, nuclear translocation and...

The effects of the AP-1 transcription factors, associated with the immune system, are largely mediated through combinatorial regulation with the NFAT, a calcium/calcineurin pathway-dependent transcription factor. The transcription factors of the NFAT family are key regulators of T cell activation [43].

2005年6月1日 · In activated T cells, NFAT proteins synergize with activator protein 1 (AP1) transcription factors at composite sites that are located in the promoters and enhancers of many cytokine genes.

2019年4月24日 · The transcription factor nuclear factor of activated T cells (NFAT) has a key role in both T cell activation and tolerance and has emerged as an important target of immune modulation. NFAT directs the effector arm of the immune response in the presence of activator protein-1 (AP-1), and T cell anergy/exhaustion in the absence of AP-1.

2021年7月27日 讯 /生物谷BIOON/ --转录因子—活化T细胞核因子（NFAT，nuclear factor of activated T cells）和激活蛋白1（AP-1）能互相合作来促进T细胞的效应功能，但NFAT在AP-1缺失时会施加一种T细胞低反应性（耗竭）的负反馈程序。 与肿瘤的斗争似乎是一场马拉松，而不是短跑，对于抗癌T细胞而言，比赛的. 2021年7月27日 讯 /生物谷BIOON/ --转录因子—活化T细胞核因子（NFAT，nuclear factor of activated T cells）和激活蛋白1（AP-1）能互相合作来促进T细 …

2019年5月14日 · NFAT directs the effector arm of the immune response in the presence of activator protein-1 (AP-1), and T cell anergy/exhaustion in the absence of AP-1. Envisioning a strategy for selective modulation of the immune response, we designed a FRET-based high-throughput screen to identify compounds that disrupt the NFAT:AP-1:DNA complex.

2001年4月30日 · The four calcium-regulated transcription factors of the NFAT family act synergistically with AP-1 (Fos/Jun) proteins on composite DNA elements which contain adjacent NFAT and AP-1 binding sites, where they form highly stable ternary complexes to regulate the expression of diverse inducible genes.

2010年8月20日 · NFAT–AP1 (activator protein 1) complexes induce interleukin-2 (IL2) expression. NFAT–FOXP3 complexes, however, inhibit IL2 expression but induce the expression of CD25 and cytotoxic T ...

NFAT directs the effector arm of the immune response in the presence of activator protein-1 (AP-1), and T cell anergy/exhaustion in the absence of AP-1. Envisioning a strategy for selective modulation of the immune response, we designed a FRET-based high-throughput screen to identify compounds that disrupt the NFAT:AP-1:DNA complex.

2023年9月22日 · 在人类和小鼠肿瘤中以及小鼠慢性感染模型中，CD8+ T细胞的转录因子NFAT5上调，但其只在高渗透肿瘤微环境中才活跃，它加剧了NFAT1和NFAT2介导的耗竭特征。