Autophagy in Neurons - PubMed
2019年10月6日 · Here we review the core components of the pathway for autophagosome biogenesis, as well as the cell biology of bulk and selective autophagy in neurons. Finally, we discuss the role of autophagy in neuronal development, homeostasis, and aging and the links between deficits in autophagy and neurodegeneration.
Neuronal Autophagy Regulates Presynaptic Neurotransmission …
2021年1月20日 · Neurons are known to rely on autophagy for removal of defective proteins or organelles to maintain synaptic neurotransmission and counteract neurodegeneration. In spite of its importance for neuronal health, the physiological substrates of neuronal autophagy in the absence of proteotoxic challenge h …
Short-term fasting induces profound neuronal autophagy - PMC
We use the method to identify constitutive autophagosomes in cortical neurons and Purkinje cells, and we show that short-term fasting leads to a dramatic upregulation in neuronal autophagy. The increased neuronal autophagy is revealed by changes in autophagosome abundance and characteristics, and by diminished neuronal mTOR activity in vivo ...
Neuronal Autophagy: Characteristic Features and Roles in Neuronal …
2021年11月1日 · Autophagy is an important degradative pathway that eliminates misfolded proteins and damaged organelles from cells. Autophagy is crucial for neuronal homeostasis and function. A lack of or deficiency in autophagy leads to the accumulation of protein aggregates, which are associated with several neur …
Neuronal autophagy and neurodegenerative diseases
2012年1月19日 · In this review, we consider both the normal and pathophysiological roles of neuronal autophagy and its potential therapeutic implications for common neurodegenerative diseases. Neurons have...
Autophagy, aging, and age-related neurodegeneration: Neuron
2024年10月14日 · This review discusses the links between the autophagy pathway, aging, and age-associated neurodegeneration in Alzheimer’s, Parkinson’s, motor neuron, and Huntington’s diseases. The authors highlight the functions of autophagy in neurons and glia and how aging and neurodegenerative diseases affect autophagy.
Autophagy in Neurons - PMC - National Center for …
2019年10月6日 · Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein aggregates. Autophagy is particularly important in neurons, terminally differentiated cells that must last the lifetime of the organism.
Autophagy in neuronal physiology and disease - ScienceDirect
2021年10月1日 · In this review, we will review recent literature on (1) emerging evidence for autophagy in regulating neurodevelopment, synaptic remodeling, neurotransmission, and neuroplasticity and (2) how neuronal autophagy regulates information processing, memory encoding, or specific dimensions of behaviors, such as cognition, as well as their ...
Mechanisms of autophagy–lysosome dysfunction in ... - Nature
2024年8月6日 · Autophagy is a lysosome-based degradative process used to recycle obsolete cellular constituents and eliminate damaged organelles and aggregate-prone proteins. Their...
Neuronal Autophagy Regulates Presynaptic Neurotransmission by ...
2021年1月20日 · We propose a model where neuronal autophagy controls axonal ER calcium stores to regulate neurotransmission in healthy neurons and in the brain. Information processing in the brain critically relies on the relay of information from a presynaptic neuron to the postsynapse via regulated neurotransmitter release.