Neurexins (NRXN) are a family of presynaptic cell adhesion proteins that have roles in connecting neurons at the synapse. [1] . They are located mostly on the presynaptic membrane and …

2021年1月8日 · Recent studies on the Neurexin protein family and its ligands provide fundamental insight into how synapses are assembled and remodelled, how synaptic properties are …

2021年4月22日 · In neurexin-deficient synapses, activation of presynaptic GABA B-receptors produced a much smaller suppression of release probability, leading to a decreased inhibition …

具体而言，作者首先总结了目前从各种动物模型中获得的对Neurexin功能的发现。 然后，作者讨论了Neurexin亚型在不同类型细胞中，特别是在可变mRNA剪接水平上，特异性调节的逻辑和机 …

2008年10月15日 · Neurexins and neuroligins are synaptic cell-adhesion molecules that connect presynaptic and postsynaptic neurons at synapses, mediate signalling across the synapse, …

Neurexins act predominantly at the presynaptic terminal in neurons and play essential roles in neurotransmission and differentiation of synapses. Some of these functions require the …

2023年9月1日 · Neurexin-3 is primarily localized in the presynaptic membrane and forms complexes with various ligands located in the postsynaptic membrane. Neurexin-3 has …

2015年7月30日 · Neurexins are evolutionarily conserved presynaptic cell-adhesion molecules that engage in trans-synaptic interactions with multifarious postsynaptic ligands, including …

Neurexin分子是一种可遗传基因，国际研究组织基本认可遗传基因中的Neurexin分子是导致人类患孤独症的“罪魁祸首”。 2017年4月13日，国际顶尖发育生物学杂志《发育细胞 …

Neurexins are type I transmembrane proteins with a single path transmembrane helix (TM) that separates amino-terminal extracellular from cytosolic intracellular domains.