2025年3月30日 · NEU1 (Neuraminidase 1) is a Protein Coding gene. Diseases associated with NEU1 include Neuraminidase Deficiency and Glycoproteinosis. Among its related pathways are Diseases of glycosylation and Synthesis of substrates in N-glycan biosythesis.

该基因编码的蛋白质是一种溶酶体酶，可从糖蛋白和糖脂等底物上切割末端唾液酸残基。 在溶酶体中，这种酶与 β-半乳糖苷酶和组织蛋白酶 A (后者也称为“保护蛋白”) 一起是异源三聚体复合物的一部分。 该基因的突变可导致唾液酸贮积症，这是一种溶酶体贮积病，可以是晚发的 1 型 (樱桃红斑肌阵挛综合征或正常体型) ，也可以是早发的 2 型 (畸形型) 严重程度增加的年龄。 [RefSeq 提供，2008 年 7 月]

2023年3月27日 · Here, we characterize the role of neuraminidase 1 (NEU1) in unilateral ureteral obstruction (UUO) and folic acid (FA)-induced renal fibrosis mouse models. We find that NEU1 is significantly...

2021年7月5日 · 机制研究表明，NEU1在压力过载的刺激下发生核转位，入核后选择性结合GATA4，促进GATA4与胚胎基因——Nppa、Nppb基因启动子的结合并激活其转录和表达，进而诱导心肌肥厚。 图5 | 来源：European Heart Journal. 科学家们进一步探索以NEU1为靶点的抑制剂。 利用计算机辅助药物设计策略，他们从160万个化合物中筛选到16个能与NEU1形成合理氢键的化合物（C-01到C-16），并确定化合物C-09可通过靶向NEU1改善病理性心肌肥厚。

2023年5月19日 · Neuraminidase-1 (sialidase-1 or NEU1) is a ubiquitously expressed mammalian sialidase located in lysosomes and on the cell membrane. Because of its modulation of multiple signaling processes, it is a potential therapeutic target for cancers and immune disorders.

Enables exo-alpha-sialidase activity. Predicted to be involved in several processes, including ganglioside catabolic process; positive regulation of neuron projection development; and regulation of myoblast proliferation. Predicted to act upstream of or within carbohydrate metabolic process and lipid catabolic process. Located in lysosome.

Neuraminidase 1 (NEU1) is a lysosomal sialidase that cleaves terminal α-linked sialic acid residues from sialylglycans. NEU1 is biosynthesized in the rough endoplasmic reticulum (RER) lumen as an N-glycosylated protein to associate with its protective protein/cathepsin A (CTSA) and then form a lysos …

The NEU1 gene provides instructions for making an enzyme called neuraminidase 1 (NEU1), which is found in lysosomes. Lysosomes are compartments within cells that use enzymes to digest and recycle materials.

The hydrolysis substrates of Neu1 are varied, and strongly linked to the structure and function of cell surface receptors. Recent evidence indicates that Neu1 has recently emerged as a central target in sialidase-mediated regulation of diseases development, and plays a much more profound role in human diseases than previously expected.

2021年6月30日 · 研究人员进一步探索以 neu1 为靶点的抑制剂筛选研究，从 160 万个化合物中筛选到 16 个最具潜力的化合物；通过 neu1 酶活力检测、亲和力评价、细胞和整体动物水平验证，发现化合物 c-09 可通过靶向 neu1 改善病理性心肌肥厚。