靶点梳理 | 肿瘤标志物之Nectin-4 - 知乎 - 知乎专栏
Nectin-4(Nectin cell adhesion molecule 4)是Nectin和Nectin样家族的细胞粘附分子，在正常的胚胎和胎儿组织中含量很高，而在成人健康组织中表达量很低。 Nectin-4是一种I型膜蛋白，二聚 …
ADC赛道新型靶点Nectin-4 - mabnus.cn
2025年1月6日 · 靶向Nectin-4的治疗方式主要是抗体药物偶联物（ADC），Enfortumab vedotin（EV）是一种针对Nectin-4的抗体药物偶联物（ADC），已获得FDA批准用于治疗尿 …
Therapeutic prospects of nectin-4 in cancer: applications and value
Nectin-4 is a Ca 2+-independent immunoglobulin-like protein that exhibits significantly elevated expression in malignant tumors while maintaining extremely low levels in healthy adult tissues. …
Nectin-4: A promising prognostic marker and therapeutic target …
2025年1月1日 · Nectin cell adhesion protein 4 (Nectin-4), a calcium-independent immunoglobulin-like protein, has garnered significant attention in oncology due to its pronounced …
Nectin cell adhesion molecule-4 (NECTIN-4): A potential target …
2021年11月15日 · NECTIN-4 [a poliovirus receptor-related-4 (pvrl-4) encoded protein] is a Ca2+ independent immunoglobulin-like protein. Along with other Nectins (Nectin-1, -2 and -3), it is …
Nectin-4: A promising prognostic marker and therapeutic target …
Nectin cell adhesion protein 4 (Nectin-4), a calcium-independent immunoglobulin-like protein, has garnered significant attention in oncology due to its pronounced overexpression in malignant …
ADC赛道新兴靶点：Nectin-4 - 雪球
2024年11月5日 · Nectin-4，又称脊髓灰质炎病毒受体相关蛋白4 (PVRL4)，是由NECTIN4基因编码的一种分子质量在66kDa左右的跨膜细胞粘附分子，编码基因位于1q23.3上，属于免疫球蛋白 …
NECTIN4 Gene - Nectin Cell Adhesion Molecule 4
2025年3月30日 · NECTIN4 (Nectin Cell Adhesion Molecule 4) is a Protein Coding gene. Diseases associated with NECTIN4 include Ectodermal Dysplasia-Syndactyly Syndrome 1 and Measles. …
【绘真科普】细说Nectin-4蛋白与癌症之间的发生、预后和靶向治 …
Nectin-4蛋白表达会通过激活PI3K/Akt途径，进而促进肿瘤细胞增殖、分化、迁移、侵袭，高度影响肿瘤的临床病理特征和预后[1]。因此，Nectin-4作为肿瘤的诊治的又一信号，相关的治疗药 …
Targeted therapeutic strategies for Nectin-4 in breast cancer: …
2025年2月1日 · Nectin-4 is a biomarker that is specifically expressed in tumors and serves as both a diagnostic and prognostic indicator for breast cancer. Nectin-4 is involved in several …