Nectins and Nectin-like molecules (Necl) are families of cellular adhesion molecules [1] involved in Ca 2+ -independent cellular adhesion. [2][3] Nectins are ubiquitously expressed and have adhesive roles in a wide range of tissues such as the adherens junction of epithelia or the chemical synapse of the neuronal tissue.

2025年3月30日 · NECTIN2 (Nectin Cell Adhesion Molecule 2) is a Protein Coding gene. Diseases associated with NECTIN2 include Herpes Simplex and Combined Oxidative Phosphorylation Deficiency 8 . Among its related pathways are Cell junction organization and Sertoli-Sertoli Cell Junction Dynamics .

Nectin-2(CD112)多种类型的肿瘤中（例如 急性髓细胞性白血病 、 多发性骨髓瘤 和 上皮癌 ）表达上调。 CD112与 胆囊癌 的侵袭和预后不良相关，同时也有研究发现，CD112可能在CD155不表达的肿瘤组织中高表达。

Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein. [5] This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig …

Recent findings have revealed that nectin-2 is expressed in the specific areas of the brain and plays important roles, such as homeostasis of astrocytes and neurons and the formation of synapses. Moreover, a single nucleotide polymorphism in the human NECTIN2 gene is associated with Alzheimer's disease.

Nectin‐2 is an adhesion molecule that has been reported to play a role in tumor growth, metastasis and tumor angiogenesis. Herein, we investigated Nectin‐2 in ovarian cancer patients and in cell culture.

2021年10月11日 · Recent findings have revealed that nectin-2 is expressed in the specific areas of the brain and plays important roles, such as homeostasis of astrocytes and neurons and the formation of synapses. Moreover, a single nucleotide polymorphism in the human NECTIN2 gene is associated with Alzheimer's disease.

Nectin2 influences cell apoptosis by regulating ANXA2 expression in neuroblastoma. Metabolic Overlap between Alzheimer's Disease and Metabolic Syndrome Identifies the PVRL2 Gene as a New Modulator of Diabetic Dyslipidemia.

2013年6月12日 · The anti-Nectin-2 mAbs demonstrated antibody-dependent cellular cytotoxicity (ADCC) and epitope bin-dependent features such as the inhibition of Nectin-2-Nectin-2 interaction, Nectin-2-Nectin-3 interaction, and in vitro cancer cell proliferation.

该基因编码单程 I 型膜糖蛋白，具有两个 Ig 样 C2 型结构域和一个 Ig 样 V 型结构域。 这种蛋白质是粘附连接的质膜成分之一。 它还作为单纯疱疹病毒和伪狂犬病毒的某些突变株的入口，并参与这些病毒的细胞间传播。 该基因的变异与多发性硬化症严重程度的差异有关。 已经表征了编码不同亚型的替代转录剪接变体。 [RefSeq 提供，2008 年 7 月] This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain.