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Here we report a cooperative Nano-CRISPR scaffold (Nano-CD) that utilizes a specific sgRNA, selected from a functional screen for triggering endogenous GDSME expression, while releasing cisplatin to initiate immunologic cell death.

Feb 11, 2023 · Here we present a cooperative Nano-CRISPR scaffold (Nano-CD), self-supplying GSDME, developed for intracellular pyroptosis-based immunotherapy. Briefly, Nano-CD is fabricated by coating a...

Feb 14, 2023 · 2月11日，四川大学华西医院巩长旸等合作在《Nature Communiactions》上发表研究论文“A cooperative nano-CRISPR scaffold potentiates immunotherapy via activation of tumour-intrinsic pyroptosis”，构建了一种Nano-CRISPR支架（Nano-CD），该支架利用从功能筛选中选择的特定sgRNA来触发内源性GDSME ...

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Shengzhen University Topics:Quality Assessment, Low-level Vision, Large Multi-modality Models, GAME AI - Nano-cd

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